Circulating microRNAs: molecular microsensors in gastrointestinal cancer
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Circulating microRNAs: molecular microsensors in gastrointestinal cancerAuthor(s)
Date
2012-07-09Citation
Blanco-Calvo M, Calvo L, Figueroa A, Haz-Conde M, Antón-Aparicio L, Valladares-Ayerbes M. Circulating microRNAs: molecular microsensors in gastrointestinal cancer. Sensors (Basel) [Internet]. 2012 Jul 9 [acceso 2018 Ene 17];12(7):9.349-9362. Disponible en: http://www.mdpi.com/1424-8220/12/7/9349/htm
Abstract
[Abstract] MicroRNAs (miRNAs) are small molecules of single strand non-coding RNAs, which are able to regulate gene expression. miRNAs have been involved in multiple cellular processes, such as proliferation, apoptosis and differentiation, thus alterations in miRNA expression have been shown to be directly linked with the pathological origin of multiple diseases, including cancer. In this way, during last few years, an increasing number of exciting advances have contributed to the understanding of miRNA roles in cancer. Moreover, researchers have exploited the special characteristics of miRNAs, such as the tissue and disease specificity or miRNA presence in blood, to explore their use as non-invasive tumour markers. In the present review, we summarize the current data on the potential usefulness of circulating miRNAs as diagnostic and prognostic tools in gastrointestinal tumours.
Keywords
Circulating microRNAs
Biomarker
Gastrointestinal cancer
Oesophageal cancer
Gastric cancer
Pancreatic cancer
Liver cancer
Colorectal cancer
Biomarker
Gastrointestinal cancer
Oesophageal cancer
Gastric cancer
Pancreatic cancer
Liver cancer
Colorectal cancer
Description
Review
Editor version
Rights
Atribución 3.0 España
ISSN
1424-8220
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