Cyclooxygenase-2 (COX-2): a molecular target in prostate cancer
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Cyclooxygenase-2 (COX-2): a molecular target in prostate cancerAuthor(s)
Date
2007-12-15Citation
Aparicio Gallego G, Díaz Prado S, Jiménez Fonseca P, García Campelo R, Cassinello Espinosa J, Antón Aparicio LM. Cyclooxygenase-2 (COX-2): a molecular target in prostate cancer. Clin Transl Oncol. 2007;9(11):694-702
Abstract
[Abstract] Epidemiological studies provided the first evidence that COX may be involved in the pathogenesis of cancer. In the process of carcinogenesis and in the route of intracellular signalling during carcinogenesis, COX-2 expression may be a universal phenomenon. In general, COX-2 is up-regulated throughout the tumorigenic process, from early hyperplasia to metastatic disease. COX-2 has been reported to be constitutively overexpressed in a variety of malignancies and is frequently constitutively elevated in prostate carcinoma. COX-2 was consistently overexpressed in premalignant lesions such as prostatic intraepithelial neoplasia, and carcinoma. Cases are described with evolution of proliferative inflammatory atrophy of the prostate and prostate carcinoma. The increase of evidence implicating COX-2 in cancer has stimulated clinical trials to investigate the efficacy of selective COX-2 inhibitors in individuals at risk for human cancer. Regarding prostate carcinoma there is much direct or indirect evidence to support the use of COX-2 inhibitors in this disease. Trials using these drugs in familial adenomatous polyposis (FAP) and other patients with a high risk of colorectal carcinoma are ongoing.
Keywords
Prostate cancer
Cyclooxygenase-2
Inhibitors
Pharmacological treatment
Molecular target
Cyclooxygenase-2
Inhibitors
Pharmacological treatment
Molecular target
Editor version
Rights
The final publication is avaliable at Springer Link
ISSN
1699-048X
1699-3055
1699-3055