Molecular characterization of HIV-1 infection in Northwest Spain (2009–2013): investigation of the subtype F outbreak
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Molecular characterization of HIV-1 infection in Northwest Spain (2009–2013): investigation of the subtype F outbreakAutor(es)
Fecha
2014-12-16Cita bibliográfica
Paraskevis D, Kostaki E, Beloukas, et al. Molecular characterization of HIV-1 infection in Northwest Spain (2009–2013): investigation of the subtype F outbreak. Infec Genet Evol. 2015;30:96-101
Resumen
[Abstract] Background. HIV-1 subtype B is the predominant one in European regions several, while other subtypes and recombinants are also circulating with high prevalence. A sub-epidemic of subtype F with specific characteristics and low response to treatment has been recently identified in Galicia. In this study we investigated the characteristics of the HIV-1 subtype F sub-epidemic in A Coruña and Santiago de Compostela in Northwest Spain.
Methods. 420 newly HIV-1 diagnosed patients during 2009–2013 were enrolled in this study. HIV-1 subtyping was carried out using automated subtyping tools and phylogenetic analysis. Molecular epidemiology investigation of subtypes B and F was performed by means of phylogenetic analysis using fast maximum likelihood. Phylodynamic analysis was performed using Bayesian method as implemented in BEAST v1.8.
Results. Subtype B found to be the predominant (61.2% and 70.4%) followed by subtype F (25.6% and 12.0%) in both areas (A Coruña and Santiago de Compostela, respectively). The latter found to mainly spread among men having sex with men (MSM). The vast majority of subtype F lineages from both areas clustered monophyletically, while subtype B sequences clustered in several tree branches. The exponential growth of subtype F sub-epidemic dated back in 2008 by means of phylodynamic analysis. Most of new infections during 2009–2013 occurred within the subtype F transmission cluster.
Conclusions. Subtype F circulates at high prevalence in A Coruña and Santiago de Compostela in Northwest Spain, suggesting that the HIV-1 epidemic in this region has distinct characteristics to the rest of Spain. Subtype F has being spreading among MSM and is currently the most actively spreading network. The single cluster spread of this local sub-epidemic might provide an explanation for the distinct characteristics and the low response to antiretroviral treatment.
Palabras clave
HIV-1
Subtype F
Galicia
Spain
Local sub-epidemic
Molecular epidemiology
Subtype F
Galicia
Spain
Local sub-epidemic
Molecular epidemiology
Versión del editor
Derechos
Atribución-NoComercial-SinDerivadas 3.0 España
ISSN
1567-1348
1567-7257
1567-7257