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Treatment adherence to pegvisomant in patients with acromegaly in Spain: PEGASO study
(Springer, 2019-02-13)
[Abstract] PURPOSE: The burden of chronic daily subcutaneous administration of pegvisomant on adherence has not been previously studied. This study was aimed to determine the adherence to pegvisomant treatment in acromegaly ...
Treatment with growth hormone for adults with growth hormone deficiency syndrome: benefits and risks
(MDPI, 2018-03-17)
[Abstract] Pharmacological treatment of growth hormone deficiency (GHD) in adults began in clinical practice more than 20 years ago. Since then, a great volume of experience has been accumulated on its effects on the ...
Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3
(Public Library of Science (PLoS), 2019-11-07)
[Abstract]
Mkrn3, the maternally imprinted gene encoding the makorin RING-finger protein-3, has
recently emerged as putative pubertal repressor, as evidenced by central precocity caused
by MKRN3 mutations in humans; ...
Compared decline of residual kidney function in patients treated with automated peritoneal dialysis and continuous ambulatory peritoneal dialysis: a multicenter study
(Karger, 2015-01-08)
[Abstract] BACKGROUND: There is controversy concerning the compared rates of decline of residual kidney function (RKF) in patients treated with continuous ambulatory peritoneal dialysis (CAPD) and automated peritoneal ...
Deregulation of miR-324/KISS1/kisspeptin in early ectopic pregnancy: mechanistic findings with clinical and diagnostic implications
(Elsevier, 2019-05)
[Abstract] BACKGROUND:
Ectopic pregnancy is a life-threatening condition for which novel screening tools that would enable early accurate diagnosis would improve clinical outcomes. Kisspeptins, encoded by KISS1, play ...
Influence of Age on Rat Bone-Marrow Mesenchymal Stem Cells Potential
(Nature, 2015-11-19)
[Abstract] Mesenchymal stem cells promising role in cell-based therapies and tissue engineering appears to be limited due to a decline of their regenerative potential with increasing donor age. Six age groups from bone ...
Low serum levels of vitamin D are associated with progression of subclinical atherosclerotic vascular disease in peritoneal dialysis patients: a prospective, multicenter study
(Karger, 2017-02-25)
[Abstract] Background: The prevalence of subclinical atherosclerosis and the main predictors of progression of this condition in patients undergoing peritoneal dialysis (PD) have been insufficiently investigated. Objectives ...
Importance of exercise in the control of metabolic and inflammatory parameters at the moment of onset in type 1 diabetic subjects
(Thieme, 2014-05-05)
[Abstract] The onset of type 1 diabetes coincides with the final phase of β-cell destruction. In some cases, this period is characterized by the presence of a functional reserve of β-cells, favouring an adequate metabolic ...
Ghrelin neutralization during fasting-refeeding cycle impairs the recuperation of body weight and alters hepatic energy metabolism
(Elsevier, 2011)
[Abstract] Ghrelin, a hormone whose levels increase during food deprivation, plays a pivotal role in the regulation of food intake, energy metabolism and storage, as well as in insulin sensitivity. Here, we investigated ...
Changes in hypothalamic expression of the Lin28/let-7 system and related MicroRNAs during postnatal maturation and after experimental manipulations of puberty
(Endocrine Society, 2013)
[Abstract] Lin28 and Lin28b are related RNA-binding proteins that inhibit the maturation of miRNAs of the let-7 family and participate in the control of cellular stemness and early embryonic development. Considerable ...