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Importance of exercise in the control of metabolic and inflammatory parameters at the moment of onset in type 1 diabetic subjects
(Thieme, 2014-05-05)
[Abstract] The onset of type 1 diabetes coincides with the final phase of β-cell destruction. In some cases, this period is characterized by the presence of a functional reserve of β-cells, favouring an adequate metabolic ...
Ghrelin neutralization during fasting-refeeding cycle impairs the recuperation of body weight and alters hepatic energy metabolism
(Elsevier, 2011)
[Abstract] Ghrelin, a hormone whose levels increase during food deprivation, plays a pivotal role in the regulation of food intake, energy metabolism and storage, as well as in insulin sensitivity. Here, we investigated ...
Changes in hypothalamic expression of the Lin28/let-7 system and related MicroRNAs during postnatal maturation and after experimental manipulations of puberty
(Endocrine Society, 2013)
[Abstract] Lin28 and Lin28b are related RNA-binding proteins that inhibit the maturation of miRNAs of the let-7 family and participate in the control of cellular stemness and early embryonic development. Considerable ...
Circulating levels of irisin in hypopituitary and normal subjects
(PLoS ONE, 2016-07-29)
[Abstract] Context. The recently identified myokine irisin conveys some of the benefits of exercise. Hypopituitarism with adult growth hormone deficiency (HP) is a situation characterized by decreased GH secretion and an ...
Cost-effectiveness analysis of preoperative treatment of acromegaly with somatostatin analogue on surgical outcome
(Elsevier, 2015-08-20)
[Abstract] Context. There is no uniform standard of care for acromegaly. Due to the high costs involved, steps must be taken to ensure the cost-effective delivery of treatment.
Objective. Taking the results of an earlier ...
Oral glucose-stimulated growth hormone (GH) test in adult GH deficiency patients and controls: potential utility of a novel test
(Elsevier para European Federation of Internal Medicine, 2017-06-09)
[Abstract] Context. The diagnosis of adult GH deficiency requires confirmation with a GH stimulation test. Oral glucose (OG) administration affects GH secretion, initially decreasing and subsequently stimulating GH ...
FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle
(Nature, 2016-07-19)
[Abstract] Irisin is processed from fibronectin type III domain-containing protein 5 (FNDC5). However, a controversy exists concerning irisin origin, regulation and function. To elucidate the relationship between serum ...
Giant non-functioning pituitary adenoma: clinical characteristics and therapeutic outcomes
(Thieme, 2020-01-02)
[Abstract] Background: Giant pituitary adenoma (≥4 cm) is a rare tumor whose clinical features and prognosis are not well known.
Aim: To evaluate the clinical characteristics and therapeutic outcomes of giant non-functioning ...
Craniopharyngioma in the elderly: a multicenter and nationwide study in Spain
(Karger, 2020-10-09)
[Abstract] Background: Craniopharyngioma (CP) is a rare tumor in the elderly whose clinical features and prognosis are not well known in this population. Aim: To evaluate the clinicopathological features and therapeutic ...