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2019 EACTS Expert Consensus on long-term mechanical circulatory support
(Oxford, 2019-05-17)
[Abstract] Long-term mechanical circulatory support (LT-MCS) is an important treatment modality for patients with severe heart failure. Different devices are available, and many—sometimes contradictory—observations regarding ...
Syncope in patients with transthyretin amyloid cardiomyopathy: clinical features and outcomes
(Taylor & Francis, 2022-03-23)
[Abstract] Background: We aimed to describe the clinical characteristics, underlying causes and outcomes of syncope in patients with transthyretin amyloid cardiomyopathy (ATTR-CM).
Methods: The clinical profile and ...
Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure
(Massachusetts Medical Society, 2020-11-13)
[Abstract]
BACKGROUND.
The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction.
Its effect on cardiovascular ...
Impact of Donor-Recipient Age on Cardiac Transplant Survival. Subanalysis of the Spanish Heart Transplant Registry
(Elsevier, 2020-06-26)
[Abstract]
Introduction and objectives.
The age of heart transplant recipients and donors is progressively increasing. It is likely that not all donor-recipient age combinations have the same impact on mortality. The ...
Omecamtiv Mecarbil in Chronic Heart Failure With Reduced Ejection Fraction: GALACTIC‐HF Baseline Characteristics and Comparison With Contemporary Clinical Trials
(Willey Online Library, 2020-09-20)
[Abstract]
Aims
The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is being tested in the Global Approach ...
Determinants of Maximal Oxygen Uptake in Patients With Heart Failure
(Wiley Online Library, 2021-03-27)
[Abstract] Aims Maximum oxygen uptake (VO₂max) is an essential parameter to assess functional capacity of patients with heart failure (HF). We aimed to identify clinical factors that determine its value, as they have not ...
Impact of intrapatient blood level variability of calcineurin inhibitors on heart transplant outcomes
(Elsevier, 2021-03-18)
[Abstract]
Introduction and objectives.
Intrapatient blood level variability (IPV) of calcineurin inhibitors has been associated with poor outcomes in solid-organ transplant, but data for heart transplant are scarce. ...
Prognostic value of serum lactate levels in patients undergoing urgent heart transplant: a subanalysis of the ASIS-TC spanish multicenter study
(Elsevier, 2018-05-30)
[Abstract] Introduction and objectives. To study the prognostic value of serum lactate in patients under temporary preoperative mechanical circulatory support who underwent urgent heart transplant.
Methods. We conducted ...
Preoperative toxoplasma gondii serostatus does not affect long-term survival of cardiac transplant recipients: analysis of the Spanish Heart Transplantation Registry
(Elsevier, 2017-10-07)
[Abstract] Background. It's unclear whether pre-transplant T. gondii seropositivity is associated with impaired survival in heart transplant recipients.
Objectives. To test the above-mentioned hypothesis in the Spanish ...
Mitochondrial Pyruvate Carrier Abundance Mediates Pathological Cardiac Hypertrophy
(Springer Nature, 2020-10-26)
[Abstract]
Cardiomyocytes rely on metabolic substrates, not only to fuel cardiac output, but also for growth and remodelling during stress. Here we show that mitochondrial pyruvate carrier (MPC) abundance mediates ...