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Proteome Analysis During Chondrocyte Differentiation in a New Chondrogenesis Model Using Human Umbilical Cord Stroma Mesenchymal Stem Cells
(American Society for Biochemistry and Molecular Biology, 2011-10-17)
[Abstract] Umbilical cord stroma mesenchymal stem cells were differentiated toward chondrocyte-like cells using a new in vitro model that consists of the random formation of spheroids in a medium supplemented with fetal ...
Cryopreservation effect on proliferative and chondrogenic potential of human chondrocytes isolated from superficial and deep cartilage
(Bentham Open, 2012-04-06)
[Abstract]
Objectives: To compare the proliferative and chondrogenic potential of fresh and frozen chondrocytes isolated from superficial and deep articular cartilage biopsies.
Materials and Methodology: The study ...
Umbilical Cord as a Mesenchymal Stem Cell Source for Treating Joint Pathologies
(Baishideng, 2011-06-18)
[Abstract] Articular cartilage disorders and injuries often result in life-long chronic pain and compromised quality of life. Regrettably, the regeneration of articular cartilage is a continuing challenge for biomedical ...
The mitochondrial inhibitor oligomycin induces an inflammatory response in the rat knee joint
(BioMed Central, 2017-06-12)
[Abstract]
Background. Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether ...
Long-term effects of hydrogen sulfide on the anabolic-catabolic balance of articular cartilage in vitro
(Elsevier, 2017-08-15)
[Abstract] Healthy cartilage maintenance relies on an equilibrium among the anabolic and catabolic processes in chondrocytes. With the onset of osteoarthritis (OA), increased interleukin (IL)-1β levels induce an inhibition ...
Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1β-stimulated human articular chondrocytes
(Elsevier, 2014-07)
[Abstract] Objective. Hydrogen sulfide (H2S), the third gasotransmitter together with NO and CO, is emerging as a regulator of inflammation. To test if it might offer therapeutic value in the treatment of osteoarthritis ...
Effect of balneotherapy in sulfurous water on an in vivo murine model of osteoarthritis
(Springer, 2019-11-01)
[Abstract] Osteoarthritis (OA) is a chronic joint disease that results in progressive cartilage destruction and subsequently joint dysfunction. Growing evidence indicates beneficial impact of balneological interventions ...
Hydrogen sulfide biosynthesis is impaired in the osteoarthritic joint
(Springer, 2019-11-16)
[Abstract] Osteoarthritis (OA) is the most common form of arthritis and it is a leading cause of disability in the elderly. Its complete etiology is not known although there are several metabolic, genetic, epigenetic, and ...
Hydrogen sulfide and inflammatory joint diseases
(Bentham, 2017)
[Abstract] Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are widespread rheumatic diseases characterized by persistent inflammation and joint destruction. Hydrogen sulfide (H2S) is an endogenous gas with ...
Human cartilage engineering in an in vitro repair model using collagen scaffolds and mesenchymal stromal cells
(Ivyspring, 2017-09-28)
[Abstract] The purpose of this study was to investigate cartilage repair of in vitro lesion models using human bone marrow mesenchymal stromal cells (hBMSCs) with different collagen (Col) scaffolds.
Lesions were made ...