Mostrando ítems 1-10 de 29
Regulation of Angiogenesis Discriminates Tissue Resident MSCs from Effective and Defective Osteogenic Environments
(MDPI, 2020-05-28)
[Abstract] Background: The biological mechanisms that contribute to atrophic long bone non-union
are poorly understood. Multipotential mesenchymal stromal cells (MSCs) are key contributors to bone
formation and are ...
Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage
(Elsevier, 2020-07-07)
[Abstract]
Aging is a process of cellular and tissue dysfunction characterized by different hallmarks, including cellular senescence. However, there is proof that certain features of aging and senescence can be ameliorated. ...
Mesenchymal Stromal Cells for Articular Cartilage Repair: Preclinical Studies
(AO Research Institute Davos (ARI), 2020-08-26)
[Abstract]
Rheumatic diseases such as osteoarthritis (OA) are a major social and economic burden because of the
population aging and the lack of curative solutions. An effective cell therapy may be the best treatment ...
Gene Expression Signatures of Synovial Fluid Multipotent Stromal Cells in Advanced Knee Osteoarthritis and Following Knee Joint Distraction
(Frontiers Media S.A., 2020-10-14)
[Abstract]
Osteoarthritis (OA) is the most common musculoskeletal disorder. Although joint
replacement remains the standard of care for knee OA patients, knee joint distraction
(KJD), which works by temporarily off-loading ...
Influence of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Vitro and their Role in Ageing
(Springer Nature, 2020-01-03)
[Abstract]
Introduction: This study assessed whether mesenchymal stem cell (MSC)-derived extracellular vesicles influenced
ageing and pluripotency markers in cell cultures where they are added.
Methods: MSC-derived ...
Extremophilic cyanobacteria from thermo-mineral springs of spas in Atlantic environments
(Taylor & Francis, 2022-04-12)
[Abstract] The species composition of cyanobacteria assemblages was studied in six thermo-mineral springs of spas in Atlantic environments of Galicia (NW Spain). Two are considered hot (Ta ≥ 40 °C), two intermediate (Ta ...
Patients' perceptions on shared decision making during prescription of subcutaneous biological drug treatments for inflammatory arthritis: the RHEU-LIFE survey
(Wiley, 2020-08-24)
[Abstract] Objectives: The aim of this study was to explore the preferences of patients with rheumatic diseases and their perceived experience regarding participation in shared decision making (SDM) when they were prescribed ...
Development of new non-viral systems for genetic modification of senescent cells
(Cell Press, 2023-03-20)
[Abstract] Senescence is a process characterized by a prolonged irreversible cell-cycle arrest. The accumulation of senescent cells in tissues is related to aging and to the development of age-related diseases. Recently, ...
Genome Wide CRISPR/Cas9 Screen Identifies the Coagulation Factor IX (F9) as a Regulator of Senescence
(Nature, 2022-02-19)
[Abstract] During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression. In this context, CDK4/6 inhibitors induce ...
Global DNA Methylation in Dental Implant Failure Due to Peri-Implantitis: An Exploratory Clinical Pilot Study
(MDPI, 2022-01-17)
[Abstract] Background: Peri-implantitis (PIT) is highly prevalent in patients with dental implants and is a challenging condition to treat due to the limited outcomes reported for non-surgical and surgical therapies. ...