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mtDNA variability determines spontaneous joint aging damage in a conplastic mouse model
(Impact Journals, 2022-07-02)
[Abstract] Mitochondria and mtDNA variations contribute to specific aspects of the aging process. Here, we aimed to investigate the influence of mtDNA variation on joint damage in a model of aging using conplastic mice. A ...
The association of the lipid profile with knee and hand osteoarthritis severity: the IMI-APPROACH cohort
(Elsevier, 2022-05-27)
[Abstract] Objective: To investigate the association of the lipidomic profile with osteoarthritis (OA) severity, considering the outcomes radiographic knee and hand OA, pain and function.
Design: We used baseline data ...
Osteoarthritis endotype discovery via clustering of biochemical marker data
(BMJ, 2022-04-08)
[Abstract] Objectives: Osteoarthritis (OA) patient stratification is an important challenge to design tailored treatments and drive drug development. Biochemical markers reflecting joint tissue turnover were measured in ...
Assessing motivational stages and processes of change for weight management around bariatric surgery: a multicenter study
(Springer Nature, 2019-06-17)
[Abstract] Introduction/purpose: The assessment of the patients' motivation as a predictor of behavioral change via five stages (pre-contemplation, contemplation, preparation, action, and maintenance) and four processes ...
Effect of long-term tafamidis treatment on health-related quality of life in patients with transthyretin amyloid cardiomyopathy
(John Wiley & Sons, 2024-03-04)
[Abstract]
Aims: To evaluate the effect of long-term tafamidis treatment on health-related quality of life (HRQoL) in patients with transthyretin amyloid cardiomyopathy (ATTR-CM) enrolled in the Tafamidis in Transthyretin ...
Pain as a mediator in the temperament-alexithymia relationship in individuals suffering from rheumatoid arthritis
(Verduci, 2021-12)
[Abstract] OBJECTIVE: The study aims to establish a relationship between temperament traits, symptoms of alexithymia, and pain intensity in rheumatoid arthritis. Despite the significant progress seen in the area of RA ...
Small extracellular vesicles have GST activity and ameliorate senescence-related tissue damage
(Elsevier, 2020-07-07)
[Abstract]
Aging is a process of cellular and tissue dysfunction characterized by different hallmarks, including cellular senescence. However, there is proof that certain features of aging and senescence can be ameliorated. ...
Low-volume cycling training improves body composition and functionality in older people with multimorbidity: a randomized controlled trial
(Nature, 2021-06-28)
[Abstract] Physical exercise, when practiced regularly and in adequate doses, is a proven nonpharmacological measure that helps to prevent and reverse noncommunicable diseases, as well as reduce mortality rates from any ...
Reduced levels of H₂S in diabetes-associated osteoarthritis are linked to hyperglycaemia, Nrf-2/HO-1 signalling downregulation and chondrocyte dysfunction
(MDPI, 2022-03-25)
[Abstract] Different findings indicate that type 2 diabetes is an independent risk factor for osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. Changes in the ...
Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort
(BioMed Central, 2022-11-17)
[Abstract] Background. The IMI-APPROACH cohort is an exploratory, 5-centre, 2-year prospective follow-up study of knee osteoarthritis (OA). Aim was to describe baseline multi-tissue semiquantitative MRI evaluation of index ...