Listar GI-EXPRELA - Artigos por título

Mostrando ítems 15-25 de 25

    • Production and characterization of an extracellular acid protease from thermophilic Brevibacillus sp. OA30 isolated from an Algerian hot spring 

      Gomri, Mohamed Amine; Rico Díaz, Agustín; Escuder-Rodríguez, Juan-José; El Moulouk Khaldi, Tedj; González-Siso, María-Isabel; Kharroub, Karima (MDPI, 2018-04-12)
      [Abstract] Proteases have numerous biotechnological applications and the bioprospection for newly-thermostable proteases from the great biodiversity of thermophilic microorganisms inhabiting hot environments, such as ...

    • Proteomic Analyses Reveal that Sky1 Modulates Apoptosis and Mitophagy in Saccharomyces cerevisiae Cells Exposed to Cisplatin 

      Rodríguez Lombardero, Silvia; Rodríguez-Belmonte, Esther; González-Siso, María-Isabel; Vizoso-Vázquez, Ángel; Valdiglesias, Vanessa; Laffon, Blanca; Cerdán, María Esperanza (Multidisciplinary Digital Publishing Institute, 2014)
      [Abstract] Sky1 is the only member of the SR (Serine–Arginine) protein kinase family in Saccharomyces cerevisiae. When yeast cells are treated with the anti-cancer drug cisplatin, Sky1 kinase activity is necessary to produce ...

    • Reactivity of a Recombinant Esterase from Thermus thermophilus HB27 in Aqueous and Organic Media 

      González González, Roberto; Fuciños, Pablo; Beneventi, Elisa; López-López, Olalla; Pampín, Begoña; Rodríguez, Ramón; González-Siso, María-Isabel; Cruces, Jacobo; Rúa Rodríguez, María Luisa (MDPI, 2022-04-27)
      [Abstract] The thermoalkalophilic membrane-associated esterase E34Tt from Thermus thermophilus HB27 was cloned and expressed in Kluyveromyces lactis (KLEST-3S esterase). The recombinant enzyme was tested as a biocatalyst ...

    • Role of the E3 Ubiquitin-Ligase Hakai in Intestinal Inflammation and Cancer Bowel Disease 

      Roca-Lema, Daniel; Quiroga, Macarena; Khare, Vineeta; Díaz-Díaz, Andrea; Barreiro-Alonso, Aida; Rodríguez-Alonso, Andrea; Concha, Ángel; Romay, Gabriela; Cerdán, María Esperanza; Gasche, Christoph; Figueroa, Angélica (Springer Nature, 2022-10-20)
      [Abstract] The E3 ubiquitin-ligases are important for cellular protein homeostasis and their deregulation is implicated in cancer. The E3 ubiquitin-ligase Hakai is involved in tumour progression and metastasis, through the ...

    • Study of ferroptosis transmission by small extracellular vesicles in epithelial ovarian cancer cells 

      Alarcón-Veleiro, Carmen; Mato-Basalo, Rocío; Lucio-Gallego, Sergio; Vidal-Pampín, Andrea; Quindós-Varela, María; Al-Qatarneh, Thamer; Berrecoso, Germán; Vizoso-Vázquez, Ángel; Arufe, M.C.; Fafián Labora, Juan Antonio (MDPI, 2023-01-12)
      [Abstract] Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. The current treatment for EOC involves surgical debulking of the tumors followed by a combination of chemotherapy. While most patients ...

    • Thanksgiving to Yeast, the HMGB Proteins History from Yeast to Cancer [Review] 

      Lamas, Mónica; Vizoso-Vázquez, Ángel; Barreiro-Alonso, Aida; Cámara-Quílez, M.; Cerdán, María Esperanza (MDPI, 2023-04-11)
      [Abstract] Yeasts have been a part of human life since ancient times in the fermentation of many natural products used for food. In addition, in the 20th century, they became powerful tools to elucidate the functions of ...

    • The Challenges and Opportunities of lncRNAs in Ovarian Cancer Research and Clinical Use 

      Salamini-Montemurri, Martín; Lamas, Mónica; Barreiro-Alonso, Aida; Vizoso-Vázquez, Ángel; Rodríguez-Belmonte, Esther; Quindós-Varela, María; Cerdán, María Esperanza (MDPI, 2020-04-21)
      [Abstract] Ovarian cancer is one of the most lethal gynecological malignancies worldwide because it tends to be detected late, when the disease has already spread, and prognosis is poor. In this review we aim to highlight ...

    • The HMGB Protein KlIxr1, a DNA Binding Regulator of Kluyveromyces lactis Gene Expression Involved in Oxidative Metabolism, Growth, and dNTP Synthesis 

      Rico Díaz, Agustín; Barreiro-Alonso, Aida; Rey-Souto, Cora; Becerra, Manuel; Lamas, Mónica; Cerdán, María Esperanza; Vizoso-Vázquez, Ángel (MDPI, 2021-08-21)
      [Abstract] In the traditional fermentative model yeast Saccharomyces cerevisiae, ScIxr1 is an HMGB (High Mobility Group box B) protein that has been considered as an important regulator of gene transcription in response ...

    • The HMGB1-2 Ovarian Cancer Interactome: the Role of HMGB Proteins and Their Interacting Partners MIEN1 and NOP53 in Ovary Cancer and Drug-Response 

      Cámara-Quílez, María; Barreiro-Alonso, Aida; Vizoso-Vázquez, Ángel; Rodríguez-Belmonte, Esther; Quindós-Varela, María; Lamas, Mónica; Cerdán, María Esperanza (MDPI, 2020-08-27)
      [Abstract] High mobility group box B (HMGB) proteins are overexpressed in different types of cancers such as epithelial ovarian cancers (EOC). We have determined the first interactome of HMGB1 and HMGB2 in epithelial ovarian ...

    • Thermus thermophilus as a Source of Thermostable Lipolytic Enzymes 

      López-López, Olalla; Cerdán, María Esperanza; González-Siso, María-Isabel (Multidisciplinary Digital Publishing Institute, 2015)
      Lipolytic enzymes, esterases (EC 3.1.1.1) and lipases (EC 3.1.1.3), catalyze the hydrolysis of ester bonds between alcohols and carboxylic acids, and its formation in organic media. At present, they represent about 20% of ...

    • Xylanases From Thermophilic Archaea: A Hidden Treasure 

      Saavedra-Bouza, Almudena; Escuder-Rodríguez, Juan-José; De Castro de Antonio, María Eugenia; Becerra, Manuel; González-Siso, María-Isabel (Elsevier, 2022-12-12)
      [Abstract] Archaea are a domain of prokaryotic organisms that often inhabit extremophilic environments. Their enzymes are therefore of enormous biotechnological interest, due to their stability and activity in harsh ...