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Role of neurokinin B in the control of female puberty and Its modulation by metabolic status
(Society of Neuroscience, 2012-02-15)
[Abstract] Human genetic studies have revealed that neurokinin B (NKB) and its receptor, neurokinin-3 receptor (NK3R), are essential elements for normal reproduction; however, the precise role of NKB–NK3R signaling in the ...
Growth hormone, ghrelin and peptide YY secretion after oral glucose administration in healthy and obese women
(Thieme, 2011-06-10)
[Abstract] The mechanism of the altered GH secretion in obesity is unclear. There is evidence that oral glucose (OG) administration initially decreases and subsequently stimulates GH secretion. Ghrelin is a peptide that ...
Effect of ghrelin on glucose-insulin homeostasis: therapeutic implications
(Hindawi, 2010)
[Abstract] Ghrelin is a 28-amino-acid peptide that displays a strong growth hormone- (GH-) releasing activity through the activation of the growth hormone secretagogue receptor (GHSR). The first studies about role of ghrelin ...
Serum levels of the adipomyokine irisin in patients with chronic kidney disease
(Elsevier, 2016-12-14)
[Abstract] Background. Irisin is an adipomyokine with claimed anti-obesity and anti-diabetic effects. This hormone has been insufficiently studied in patients with advanced chronic kidney disease (CKD).
Objective. To ...
Treatment with growth hormone for adults with growth hormone deficiency syndrome: benefits and risks
(MDPI, 2018-03-17)
[Abstract] Pharmacological treatment of growth hormone deficiency (GHD) in adults began in clinical practice more than 20 years ago. Since then, a great volume of experience has been accumulated on its effects on the ...
The decreased growth hormone response to growth hormone releasing hormone in obesity is associated to cardiometabolic risk factors
(Hindawi, 2010)
[Abstract] The aim of the present study was to evaluate the relationship between GHRH-induced GH secretion in obese premenopausal women and cardiovascular risk markers or insulin resistance. Premenopausal obese women, aged ...
Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3
(Public Library of Science (PLoS), 2019-11-07)
[Abstract]
Mkrn3, the maternally imprinted gene encoding the makorin RING-finger protein-3, has
recently emerged as putative pubertal repressor, as evidenced by central precocity caused
by MKRN3 mutations in humans; ...
Altered fasting and postprandial plasma ghrelin levels in patients with liver failure are normalized after liver transplantation
(Bioscientifica para European Society for Endocrinology, 2010)
[Abstract]
Context Anorexia is a problem of paramount importance in patients with advanced liver failure. Ghrelin has important actions on feeding and weight homeostasis. Experimental data exist, which suggest that ghrelin ...
Effect of oral glucose administration on rebound growth hormone release in normal and obese women: the role of adiposity, insulin sensitivity and ghrelin
(PLoS ONE, 2015-03-17)
[Abstract] Context. Metabolic substrates and nutritional status play a major role in growth hormone (GH) secretion. Uncovering the mechanisms involved in GH secretion following oral glucose (OG) administration in normal ...
Testicular expression of the Lin28/let-7 system: hormonal regulation and changes during postnatal maturation and after manipulations of puberty
(Nature, 2015-10-23)
[Abstract] The Lin28/let-7 system, which includes the RNA-binding proteins, Lin28a/Lin28b, and let-7 miRNAs, has emerged as putative regulator of puberty and male gametogenesis; yet, its expression pattern and regulation ...