Listar GI-FENM - Artigos por autor "Antón-Aparicio, Luis M."

Mostrando ítems 1-20 de 26

    • A primary signet ring cell carcinoma of the prostate with bone metastasis with impressive response to FOLFOX and Cetuximab 

      Roldán, Ana Milena; Fernández-Núñez, Natalia; Grande Pulido, Enrique; Álvarez-García, Augusto; Antón-Aparicio, Luis M. (Elsevier, 2012-03-10)

    • Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer 

      Valladares-Ayerbes, Manuel; Díaz-Prado, Silvia; Reboredo, Margarita; Medina Villaamil, Vanessa; Iglesias-Díaz, Pilar; Lorenzo-Patiño, María J.; García Campelo, Rosario; Haz, Mar; Santamarina, Isabel; Antón-Aparicio, Luis M. (Elsevier, 2008)
      [Abstract] Background: Detection of tumor cells in the blood, or minimal deposits in distant organs as bone marrow, could be important to identify cancer patients at high risk of relapse or disease progression. Quantitative ...

    • Cabazitaxel for metastatic castration-resistant prostate cancer: safety data from the Spanish expanded access program 

      Castellano, Daniel; Antón-Aparicio, Luis M.; Esteban, Emilio; Sánchez-Hernández, Alfredo; Germá, José Ramón; Batista, Norberto; Maroto, Pablo; Pérez-Valderrama, Begoña; Luque, Raquel; Méndez-Vidal, María José (Taylor & Francis, 2014-07-07)
      [Abstract] BACKGROUND: Based on the TROPIC study results, cabazitaxel was approved for the management of metastatic castration-resistant prostate cancer (mCRPC) progressing on or after docetaxel. METHODS: This multi-centre ...

    • Circulating microRNAs: molecular microsensors in gastrointestinal cancer 

      Blanco, Moisés; Calvo, Lourdes; Figueroa, Angélica; Haz, Mar; Antón-Aparicio, Luis M.; Valladares-Ayerbes, Manuel (MPDI, 2012-07-09)
      [Abstract] MicroRNAs (miRNAs) are small molecules of single strand non-coding RNAs, which are able to regulate gene expression. miRNAs have been involved in multiple cellular processes, such as proliferation, apoptosis and ...

    • Circulating miR-200c and miR-141 and outcomes in patients with breast cancer 

      Antolín, Silvia; Calvo, Lourdes; Blanco, Moisés; Paz Santiago, María; Lorenzo-Patiño, María J.; Haz, Mar; Santamarina, Isabel; Figueroa, Angélica; Antón-Aparicio, Luis M.; Valladares-Ayerbes, Manuel (BioMed Central, 2015)
      [Abstract] Background. The deregulation of microRNAs in both tumours and blood has led to the search for microRNAs to indicate the presence of cancer and predict prognosis. We hypothesize the deregulation of miR-200c/miR-141 ...

    • Clinical implications of epithelial cell plasticity in cancer progression 

      Antón-Aparicio, Luis M.; Blanco, Moisés; Castosa, Raquel; Concha, Ángel; Valladares-Ayerbes, Manuel; Calvo, Lourdes; Figueroa, Angélica (Elsevier, 2015)
      [Abstract] In the last few years, the role of epithelial cell plasticity in cancer biology research has gained increasing attention. This concept refers to the ability of the epithelial cells to dynamically switch between ...

    • Comprehensive lung injury pathology induced by mTOR inhibitors 

      Aparicio Gallego, Guadalupe; Medina, Vanessa; Fernández, Ovidio; Jiménez, Paula; Lema, Martina; Figueroa, Angélica; Antón-Aparicio, Luis M. (Springer para Federation of Spanish Oncology Sociesties (FESEO), 2009-08-29)
      [Abstract] Interstitial lung disease is a rare side effect of temsirolimus treatment in renal cancer patients. Pulmonary fibrosis is characterised by the accumulation of extracellular matrix collagen, fibroblast proliferation ...

    • Crossing paths in Human Renal Cell Carcinoma (hRCC) 

      Aparicio Gallego, Guadalupe; Medina Villaamil, Vanessa; Grande Pulido, Enrique; Santamarina, Isabel; Antón-Aparicio, Luis M. (MDPI, 2012-10-05)
      [Abstract] Historically, cell-signaling pathways have been studied as the compilation of isolated elements into a unique cascade that transmits extracellular stimuli to the tumor cell nucleus. Today, growing evidence ...

    • Diagnostic accuracy of small breast epithelial mucin mRNA as a marker for bone marrow micrometastasis in breast cancer: a pilot study 

      Valladares-Ayerbes, Manuel; Iglesias-Díaz, Pilar; Díaz-Prado, Silvia; Ayude, Daniel; Medina Villaamil, Vanessa; Haz, Mar; Reboredo, Margarita; Antolín, Silvia; Calvo, Lourdes; Antón-Aparicio, Luis M. (Springer-Verlag, 2009-02-17)
      [Abstract] Background. Detection of isolated tumour cells (ITC) in the blood or minimal deposits in distant organs such as bone marrow (BM) could be important to identify breast cancer patients at high risk of relapse or ...

    • Enzalutamide: a new prostate cancer targeted therapy against the androgen receptor 

      Lázaro Quintela, Martín; León Mateos, Luis; Vázquez Estévez, Sergio; Fernández Calvo, Ovidio; Anido Herranz, Urbano; Afonso Afonso, Francisco Javier; Santomé, Lucía; Antón-Aparicio, Luis M. (Elsevier, 2015-03)
      [Abstract] Enzalutamide (MDV3100), an androgen receptor-signalling inhibitor, represents the most recent compound added to the therapeutic armamentarium for the treatment of metastatic castration-resistant prostate cancer ...

    • Evaluation of the efficacy and safety of lanreotide in combination with targeted therapies in patients with neuroendocrine tumours in clinical practice: a retrospective cross-sectional analysis 

      Capdevila, Jaume; Sevilla, Isabel; Alonso, Vicente; Antón-Aparicio, Luis M.; Jiménez Fonseca, Paula; Grande, Enrique; Reina, Juan José; Manzano, José Luis; Alonso Lájara, Juan Domingo; Barriuso, Jorge; Castellano, Daniel; Medina, Javier; López, Carlos; Segura, Ángel; Carrera, Sergio; Crespo, Guillermo; Fuster, José; Munarriz, Javier; García Alfonso, Pilar (BioMed Central, 2015-07-04)
      [Abstract] Background. Based on the mechanism of action, combining somatostatin analogues (SSAs) with mTOR inhibitors or antiangiogenic agents may provide synergistic effects for the treatment of patients with neuroendocrine ...

    • Fructose transporter Glut5 expression in clear renal cell carcinoma 

      Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Valbuena Ruvira, L.; García Campelo, R.; Valladares-Ayerbes, Manuel; Grande Pulido, Enrique; Bolós Fernández, Victoria; Santamarina, Isabel; Antón-Aparicio, Luis M. (Spandidos, 2010-12-10)
      [Abstract] Renal cell carcinomas (RCC) can be subclassified for general purposes into clear cell, papillary cell, chromophobe cell carcinomas and oncocytomas. Other tumours such as collecting duct, medullary, mucinous ...

    • Glucose transporter expression and the potential role of fructose in renal cell carcinoma: a correlation with pathological parameters 

      Antón-Aparicio, Luis M.; Medina Villaamil, Vanessa; Blanco, Moisés; Valbuena Ruvira, L.; Rois, José Manuel; Valladares-Ayerbes, Manuel; García Campelo, Rosario; Bolós Fernández, Victoria; Grande Pulido, Enrique (Spandidos, 2010-07-01)
      [Abstract] All mammalian cells contain one or more members of the facilitative glucose transporter (GLUT) gene family. Glucose transporter membrane proteins (GLUT) regulate the movement of glucose between the extracellular ...

    • MicroARN circulantes en sangre de pacientes con cáncer de próstata 

      Medina Villaamil, Vanessa; Martínez-Breijo, S.; Portela-Pereira, P.; Quindós-Varela, María; Santamarina, Isabel; Antón-Aparicio, Luis M.; Gómez Veiga, Francisco (Elsevier, 2014)
      [Resumen] Introducción. Los microARN (miARN) son ARN reguladores de pequeño tamaño que no codifican para proteínas. La detección de células tumorales circulantes (CTC) proporcionaría información diagnóstica y pronóstica ...

    • Multiple biomarker tissue arrays: a computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway 

      Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Valladares-Ayerbes, Manuel; Santamarina, Isabel; Antón-Aparicio, Luis M. (BioMed Central, 2012-09-01)
      [Abstract] Background. Many studies have demonstrated genetic and environmental factors that lead to renal cell carcinoma (RCC) and that occur during a protracted period of tumourigenesis. It appears suitable to identify ...

    • Novel potential predictive markers of sunitinib outcomes in long-term responders versus primary refractory patients with metastatic clear-cell renal cell carcinoma 

      Puente, Javier; Lainez, Nuria; Dueñas, Marta; Méndez-Vidal, María José; Esteban, Emilio; Castellano, Daniel; Martínez-Fernández, Mónica; Basterretxea, Laura; Juan-Fita, María José; Antón-Aparicio, Luis M.; León, Luis; Lambea, Julio; Pérez-Valderrama, Begoña; Vázquez, Sergio; Suárez, Cristina; García del Muro, Xavier; Gallardo, Enrique; Maroto, José Pablo; Samaniego, M. Luz; Suárez-Paniagua, Beatriz; Sanz, Julián; Paramio, Jesús M. (Impact Journals, 2017-03-23)
      [Abstract] Background: Several potential predictive markers of efficacy of targeted agents in patients with metastatic renal cell carcinoma (mRCC) have been identified. Interindividual heterogeneity warrants further ...

    • Phase II Randomized Study of Figitumumab plus Docetaxel and Docetaxel Alone with Crossover for Metastatic Castration-Resistant Prostate Cancer 

      De Bono, Johann S.; Piulats, Josep María; Pandha, Hardev S.; Petrylak, Daniel P.; Saad, Fred; Antón-Aparicio, Luis M.; Sandhu, Shahneen K.; Fong, Peter; Gillessen, Silke; Hudes, Gary R.; Wang, Tao; Scranton, Judith; Pollak, Michael N. (American Association for Cancer Research, 2014-02-17)
      [Abstract] PURPOSE: Figitumumab is a human IgG2 monoclonal antibody targeting insulin-like growth factor 1 receptor (IGF-1R), with antitumor activity in prostate cancer. This phase II trial randomized chemotherapy-naïve ...

    • Potential role of sugar transporters in cancer and their relationship with anticancer therapy 

      Blanco, Moisés; Figueroa, Angélica; Grande Pulido, Enrique; García Campelo, Rosario; Antón-Aparicio, Luis M. (Hindawi, 2010-06-20)
      [Abstract] Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. ...

    • Prognostic impact of disseminated tumor cells and microRNA-17-92 cluster deregulation in gastrointestinal cancer 

      Valladares-Ayerbes, Manuel; Blanco, Moisés; Haz, Mar; Medina, Vanessa; Iglesias-Díaz, Pilar; Lorenzo-Patiño, María J.; Reboredo, Margarita; Santamarina, Isabel; Figueroa, Angélica; Antón-Aparicio, Luis M.; Calvo, Lourdes (Spandidos, 2011-07-04)
      [Abstract] The presence of tumor cells in the bone marrow (BM) could be relevant to identifying high risk of disease progression and death in gastrointestinal cancer. However, the molecular profile associated with disseminated ...

    • Prostate carcinoma and stem cells 

      Antón-Aparicio, Luis M.; Cassinello Espinosa, J.; García Campelo, Rosario; Gómez Veiga, Francisco; Díaz-Prado, Silvia; Aparicio Gallego, Guadalupe (Springer, 2007-02)
      [Abstract] Stem cells, as classically defined, are cells with a capacity to self-renew and to generate daughter cells that can differentiate down several cell lineages to form all of the cell types that are found in the ...