Listar GI-FENM - Artigos por data de publicación
Mostrando ítems 41-60 de 106
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Changes in hypothalamic expression of the Lin28/let-7 system and related MicroRNAs during postnatal maturation and after experimental manipulations of puberty
(Endocrine Society, 2013)[Abstract] Lin28 and Lin28b are related RNA-binding proteins that inhibit the maturation of miRNAs of the let-7 family and participate in the control of cellular stemness and early embryonic development. Considerable ... -
Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism
(Endocrine Society, 2013-01-21)[Abstract] Lin28 (also termed Lin28a) and Lin28b are related RNA-binding proteins, involved in the control of microRNA synthesis, especially of the let-7 family, with putative functions in early (embryo) development. ... -
Efficacy of glutamine in the prevention of acute radiation enteritis: a randomized controlled trial
(SAGE, 2013-03-07)[Abstract] Background: Acute radiation enteritis is a common adverse effect related to radiotherapy (RT). Glutamine is an immune modulator and antioxidant amino acid that can exert a protective role in patients receiving ... -
Ghrelin in obesity, physiological and pharmacological considerations
(Bentham, 2013-04)[Abstract] The aim of this review is to summarize the physiological and pharmacological aspects of ghrelin. Obesity can be defined as an excess of body fat and is associated with significant disturbances in metabolic and ... -
Place of preoperative treatment of acromegaly with somatostatin analog on surgical outcome: a systematic review and meta-analysis
(PLoS ONE, 2013-04-25)[Abstract] Context. Transsphenoidal neurosurgery is the accepted first-line treatment of acromegaly in the majority of patients. Previous studies addressing preoperative somatostatin analog (SSA) treatment and subsequent ... -
¿Dónde son más felices las personas obesas?
(Elsevier, 2013-12-14) -
MicroARN circulantes en sangre de pacientes con cáncer de próstata
(Elsevier, 2014)[Resumen] Introducción. Los microARN (miARN) son ARN reguladores de pequeño tamaño que no codifican para proteínas. La detección de células tumorales circulantes (CTC) proporcionaría información diagnóstica y pronóstica ... -
Beneficios y riesgos de la hormona del crecimiento en adultos con déficit de la misma
(Elsevier, 2014-01-28)[Resumen] La deficiencia de hormona del crecimiento («growth hormone», GH) en el adulto es un síndrome clínico plenamente reconocido que entraña consecuencias adversas para la salud. Muchas de ellas pueden ser mejoradas ... -
Perturbation of hypothalamic MicroRNA expression patterns in male rats after metabolic distress: impact of obesity and conditions of negative energy balance
(Endocrine Society, 2014-02-11)[Abstract] The hypothalamus plays a crucial role in body weight homeostasis through an intricate network of neuronal circuits that are under the precise regulation of peripheral hormones and central transmitters. Although ... -
Phase II Randomized Study of Figitumumab plus Docetaxel and Docetaxel Alone with Crossover for Metastatic Castration-Resistant Prostate Cancer
(American Association for Cancer Research, 2014-02-17)[Abstract] PURPOSE: Figitumumab is a human IgG2 monoclonal antibody targeting insulin-like growth factor 1 receptor (IGF-1R), with antitumor activity in prostate cancer. This phase II trial randomized chemotherapy-naïve ... -
Cabazitaxel for metastatic castration-resistant prostate cancer: safety data from the Spanish expanded access program
(Taylor & Francis, 2014-07-07)[Abstract] BACKGROUND: Based on the TROPIC study results, cabazitaxel was approved for the management of metastatic castration-resistant prostate cancer (mCRPC) progressing on or after docetaxel. METHODS: This multi-centre ... -
Maternal and perinatal outcomes after bariatric surgery: a spanish multicenter study
(Springer, 2014-08-15)[Abstract] Background. Bariatric surgery (BS) has become more frequent among women of child-bearing age. Data regarding the underlying maternal and perinatal risks are scarce. The objective of this nationwide study is to ... -
Correlation between glycemic control and the incidence of peritoneal and catheter tunnel and exit-site infections in diabetic patients undergoing peritoneal dialysis
(SAGE, 2014-11-01)[Abstract] Background: Diabetes mellitus, especially if complicated by poor glycemic control, portends an increased risk of infection. The significance of this association in the case of diabetic patients undergoing ... -
Obesity, adipose tissue, inflammation and update on obesity management
(Symbiosis, 2014-11-12)[Abstract] Obesity is a serious, common and growing problem. Obesity can be defined as an excess of body fat. Its clinical management is complex and frequently unsuccessful. It has only recently been regarded as a chronic ... -
Clinical implications of epithelial cell plasticity in cancer progression
(Elsevier, 2015)[Abstract] In the last few years, the role of epithelial cell plasticity in cancer biology research has gained increasing attention. This concept refers to the ability of the epithelial cells to dynamically switch between ... -
Tissue effects of glutamine in rectal cancer patients treated with preoperative chemoradiotherapy
(SENPE (Sociedad Española de Nutrición Parentelar y Entelar), 2015)[Abstract] Background: The aim was to evaluate the effects of glutamine on tumor regression and histological damage in patients with rectal patients following chemoradiotherapy previous to surgery. Material and methods: ... -
Circulating miR-200c and miR-141 and outcomes in patients with breast cancer
(BioMed Central, 2015)[Abstract] Background. The deregulation of microRNAs in both tumours and blood has led to the search for microRNAs to indicate the presence of cancer and predict prognosis. We hypothesize the deregulation of miR-200c/miR-141 ... -
Effects of oral glutamine during abdominal radiotherapy on chronic radiation enteritis: a randomized controlled trial
(Elsevier, 2015-01)[Abstract] Objective. Glutamine has been proposed as a preventive treatment for toxicity related to cancer therapies. The aim of this study was to test the efficacy of glutamine in the prevention of radiation enteritis. Methods. ... -
Enzalutamide: a new prostate cancer targeted therapy against the androgen receptor
(Elsevier, 2015-03)[Abstract] Enzalutamide (MDV3100), an androgen receptor-signalling inhibitor, represents the most recent compound added to the therapeutic armamentarium for the treatment of metastatic castration-resistant prostate cancer ... -
Effect of oral glucose administration on rebound growth hormone release in normal and obese women: the role of adiposity, insulin sensitivity and ghrelin
(PLoS ONE, 2015-03-17)[Abstract] Context. Metabolic substrates and nutritional status play a major role in growth hormone (GH) secretion. Uncovering the mechanisms involved in GH secretion following oral glucose (OG) administration in normal ...