• Baseline residual kidney function and its ensuing rate of decline interact to predict mortality of peritoneal dialysis patients 

      Pérez-Fontán, Miguel; Remón Rodríguez, César; Cunha Naveira, Marta de; Borrás Sans, Mercé; Rodríguez Suárez, Carmen; Quirós Ganga, Pedro; Sánchez Álvarez, Emilio; Rodríguez-Carmona, Ana (PLOS, 2016-07-08)
      [Abstract] Background. Baseline residual kidney function (RKF) and its rate of decline during follow-up are purported to be reliable outcome predictors of patients undergoing Peritoneal Dialysis (PD). The independent ...
    • Beneficial effects of bariatric surgery-induced by weight loss on the proteome of abdominal subcutaneous adipose tissue 

      Varela-Rodríguez, Bárbara María; Juiz-Valiña, Paula; Varela, Luis; Outeiriño-Blanco, Elena; García-Brao, María Jesús; Mena, Enrique; Noguera, José Francisco; Valero-Gasalla, Javier; Cordido, Fernando; Sangiao-Alvarellos, Susana; Bravo, Susana Belén (MDPI, 2020-01-13)
      [Abstract] Bariatric surgery (BS) is the most effective treatment for obesity and has a positive impact on cardiometabolic risk and in the remission of type 2 diabetes. Following BS, the majority of fat mass is lost from ...
    • Beneficios y riesgos de la hormona del crecimiento en adultos con déficit de la misma 

      Díez, Juan José; Cordido, Fernando (Elsevier, 2014-01-28)
      [Resumen] La deficiencia de hormona del crecimiento («growth hormone», GH) en el adulto es un síndrome clínico plenamente reconocido que entraña consecuencias adversas para la salud. Muchas de ellas pueden ser mejoradas ...
    • Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer 

      Valladares-Ayerbes, Manuel; Díaz-Prado, Silvia; Reboredo, Margarita; Medina Villaamil, Vanessa; Iglesias-Díaz, Pilar; Lorenzo-Patiño, María J.; García Campelo, Rosario; Haz, Mar; Santamarina, Isabel; Antón-Aparicio, Luis M. (Elsevier, 2008)
      [Abstract] Background: Detection of tumor cells in the blood, or minimal deposits in distant organs as bone marrow, could be important to identify cancer patients at high risk of relapse or disease progression. Quantitative ...
    • Cabazitaxel for metastatic castration-resistant prostate cancer: safety data from the Spanish expanded access program 

      Castellano, Daniel; Antón-Aparicio, Luis M.; Esteban, Emilio; Sánchez-Hernández, Alfredo; Germá, José Ramón; Batista, Norberto; Maroto, Pablo; Pérez-Valderrama, Begoña; Luque, Raquel; Méndez-Vidal, María José (Taylor & Francis, 2014-07-07)
      [Abstract] BACKGROUND: Based on the TROPIC study results, cabazitaxel was approved for the management of metastatic castration-resistant prostate cancer (mCRPC) progressing on or after docetaxel. METHODS: This multi-centre ...
    • Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion 

      Sangiao-Alvarellos, Susana; Vázquez, María J.; Varela, Luis; Nogueiras, Rubén; Saha, Asish K.; Cordido, Fernando; López, Miguel; Diéguez, Carlos (Oxford para Endocrine Society, 2009-10-01)
      [Abstract] GH plays a major role in the regulation of lipid metabolism and alterations in GH axis elicit major changes in fat distribution and mobilization. For example, in patients with GH deficiency (GHD) or in mice ...
    • Central Resistance to Thyroid Hormones in Morbidly Obese Subjects is Reversed after Bariatric Surgery-Induced Weight Loss 

      Juiz-Valiña, Paula; Cordido, María; Outeiriño-Blanco, Elena; Pértega-Díaz, Sonia; Varela-Rodríguez, Bárbara María; García-Brao, María Jesús; Mena, Enrique; Pena-Bello, Lara; Sangiao-Alvarellos, Susana; Cordido, Fernando (MDPI, 2020-01-28)
      [Abstract] Endocrine abnormalities are common in obesity, including altered thyroid function. The altered thyroid function of obesity may be due to a mild acquired resistance to the thyroid hormone. The aim of this study ...
    • Changes in hypothalamic expression of the Lin28/let-7 system and related MicroRNAs during postnatal maturation and after experimental manipulations of puberty 

      Sangiao-Alvarellos, Susana; Manfredi-Lozano, María; Ruiz-Pino, Francisco; Navarro, V.M.; Sánchez-Garrido, M.A.; León, Silvia; Diéguez, Carlos; Cordido, Fernando; Matagne, V.; Dissen, G.A.; Ojeda, S.R.; Pinilla, Leonor; Tena-Sempere, Manuel (Endocrine Society, 2013)
      [Abstract] Lin28 and Lin28b are related RNA-binding proteins that inhibit the maturation of miRNAs of the let-7 family and participate in the control of cellular stemness and early embryonic development. Considerable ...
    • Circulating angiotensin-converting enzyme 2 activity in patients with chronic kidney disease without previous history of cardiovascular disease 

      Anguiano, Lidia; Riera, Marta; Pascual, Julio; Valdivielso, José Manuel; Barrios, Clara; Betriu, Angels; Mojal, Sergi; Fernández, Elvira; Soler, María José; Pérez-Fontán, Miguel (Oxford, 2015-03-26)
      [Abstract] Background. Patients with cardiovascular (CV) disease have an increased circulating angiotensin-converting enzyme 2 (ACE2) activity, but there is little information about changes in ACE2 in chronic kidney disease ...
    • Circulating levels of irisin in hypopituitary and normal subjects 

      Pena-Bello, Lara; Pértega-Díaz, Sonia; Sangiao-Alvarellos, Susana; Outeiriño-Blanco, Elena; Eiras-Leal, Raquel; Varela-Rodríguez, Bárbara María; Juiz-Valiña, Paula; Pérez-Fontán, Miguel; Cordido, María; Cordido, Fernando (PLoS ONE, 2016-07-29)
      [Abstract] Context. The recently identified myokine irisin conveys some of the benefits of exercise. Hypopituitarism with adult growth hormone deficiency (HP) is a situation characterized by decreased GH secretion and an ...
    • Circulating microRNAs: molecular microsensors in gastrointestinal cancer 

      Blanco, Moisés; Calvo, Lourdes; Figueroa, Angélica; Haz, Mar; Antón-Aparicio, Luis M.; Valladares-Ayerbes, Manuel (MPDI, 2012-07-09)
      [Abstract] MicroRNAs (miRNAs) are small molecules of single strand non-coding RNAs, which are able to regulate gene expression. miRNAs have been involved in multiple cellular processes, such as proliferation, apoptosis and ...
    • Circulating miR-200c and miR-141 and outcomes in patients with breast cancer 

      Antolín, Silvia; Calvo, Lourdes; Blanco, Moisés; Paz Santiago, María; Lorenzo-Patiño, María J.; Haz, Mar; Santamarina, Isabel; Figueroa, Angélica; Antón-Aparicio, Luis M.; Valladares-Ayerbes, Manuel (BioMed Central, 2015)
      [Abstract] Background. The deregulation of microRNAs in both tumours and blood has led to the search for microRNAs to indicate the presence of cancer and predict prognosis. We hypothesize the deregulation of miR-200c/miR-141 ...
    • Clinical implications of epithelial cell plasticity in cancer progression 

      Antón-Aparicio, Luis M.; Blanco, Moisés; Castosa, Raquel; Concha, Ángel; Valladares-Ayerbes, Manuel; Calvo, Lourdes; Figueroa, Angélica (Elsevier, 2015)
      [Abstract] In the last few years, the role of epithelial cell plasticity in cancer biology research has gained increasing attention. This concept refers to the ability of the epithelial cells to dynamically switch between ...
    • Clinical manifestations and diagnosis of acromegaly 

      Lugo, Gloria; Pena, Lara; Cordido, Fernando (Hindawi, 2012)
      [Abstract] Acromegaly and gigantism are due to excess GH production, usually as a result of a pituitary adenoma. The incidence of acromegaly is 5 cases per million per year and the prevalence is 60 cases per million. ...
    • Comprehensive approach to peritoneal dialysis-related peritonitis by enteric microorganisms: comparison between single organism and polymicrobial infections 

      Ribera-Sánchez, Roi; Pérez-Fontán, Miguel; López-Iglesias, Antía; García-Enríquez, Alba; Rodríguez-Carmona, Ana (International Society for Pertioneal Dialysis, 2018)
      [Abstract] Background: Peritoneal infections of enteric origin (EntP) have been classically investigated using partial strategies, focused on particular subgroups of microorganisms. A more comprehensive approach may ...
    • Comprehensive lung injury pathology induced by mTOR inhibitors 

      Aparicio Gallego, Guadalupe; Medina, Vanessa; Fernández, Ovidio; Jiménez, Paula; Lema, Martina; Figueroa, Angélica; Antón-Aparicio, Luis M. (Springer para Federation of Spanish Oncology Sociesties (FESEO), 2009-08-29)
      [Abstract] Interstitial lung disease is a rare side effect of temsirolimus treatment in renal cancer patients. Pulmonary fibrosis is characterised by the accumulation of extracellular matrix collagen, fibroblast proliferation ...
    • Correlation between glycemic control and the incidence of peritoneal and catheter tunnel and exit-site infections in diabetic patients undergoing peritoneal dialysis 

      Rodríguez-Carmona, Ana; Pérez-Fontán, Miguel; López-Muñiz, Andrés; Ferreiro-Hermida, Tamara; García Falcón, María Teresa (SAGE, 2014-11-01)
      [Abstract] Background: Diabetes mellitus, especially if complicated by poor glycemic control, portends an increased risk of infection. The significance of this association in the case of diabetic patients undergoing ...
    • Cost-effectiveness analysis of preoperative treatment of acromegaly with somatostatin analogue on surgical outcome 

      Margusino-Framiñán, Luis; Pértega-Díaz, Sonia; Pena-Bello, Lara; Sangiao-Alvarellos, Susana; Outeiriño-Blanco, Elena; Pita-Gutiérrez, Francisco; Pita-Fernández, Salvador; Cordido, Fernando (Elsevier, 2015-08-20)
      [Abstract] Context. There is no uniform standard of care for acromegaly. Due to the high costs involved, steps must be taken to ensure the cost-effective delivery of treatment. Objective. Taking the results of an earlier ...
    • Cost-effectiveness analysis of second-line pharmacological treatment of acromegaly in Spain 

      Peral, Carmen; Cordido, Fernando; Gimeno-Ballester, Vicente; Mir, Nuria; Sánchez-Cenizo, Laura; Rubio-Rodríguez, Darío; Rubio-Terrés, Carlos (Taylor&Francis, 2020-05-06)
      [Abstract] Objective: To estimate the cost-effectiveness of second-line pharmacological treatments in patients with acromegaly resistant to first-generation somatostatin analogues (FG SSA) from the Spanish National ...
    • Crossing paths in Human Renal Cell Carcinoma (hRCC) 

      Aparicio Gallego, Guadalupe; Medina Villaamil, Vanessa; Grande Pulido, Enrique; Santamarina, Isabel; Antón-Aparicio, Luis M. (MDPI, 2012-10-05)
      [Abstract] Historically, cell-signaling pathways have been studied as the compilation of isolated elements into a unique cascade that transmits extracellular stimuli to the tumor cell nucleus. Today, growing evidence ...