Can pathway-specific LFPs be obtained in cytoarchitectonically complex structures?
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Can pathway-specific LFPs be obtained in cytoarchitectonically complex structures?Author(s)
Date
2014-05-01Citation
Marakova J, Ortuño T, Korovaichuk A, Cudeiro J, Marakov VA, Rivadulla C, Herreras O. Can pathway-specific LFPs be obtained in cytoarchitectonically complex structures?. Front Syst Neurosci. 2014;8:66.
Abstract
[Abstract] Deciphering how the brain encodes the continuous flow of information contained in natural stimuli requires understanding the spontaneous activity of functional assemblies in multiple neuronal populations. A promising integrative approach that combines multisite recordings of local field potentials (LFP) with an independent component analysis (ICA) enables continuous readouts of population specific activities of functionally different neuron groups to be obtained. We previously used this technique successfully in the hippocampus, a single-layer neuronal structure. Here we provide numerical evidence that the cytoarchitectonic complexity of other brain structures does not compromise the value of the ICA-separated LFP components, given that spatial sampling of LFP is representative. The spatial distribution of an LFP component may be quite complex due to folded and multilayered structure of the neuronal aggregate. Nevertheless, the time course of each LFP component is still a reliable postsynaptic convolution of spikes fired by a homogeneous afferent population. This claim is supported by preliminary experimental data obtained in the lateral geniculate nucleus of the awake monkey.
Keywords
Local field potentials
Spatial discrimination
Independent component analysis
Spontaneous activity
Network activity
Lateral geniculate nucleus
Multicompartmental neuron model
LFP model
Spatial discrimination
Independent component analysis
Spontaneous activity
Network activity
Lateral geniculate nucleus
Multicompartmental neuron model
LFP model
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Creative Commons Attribution 4.0 International Licence (CC-BY 4.0)