Listar GI-TCMR - Artigos por autor "Vaamonde-García, Carlos"

Mostrando ítems 1-11 de 11

    • 15-Deoxy-Δ-12, 14-prostaglandin J2 acts cooperatively with prednisolone to reduce TGF-β-induced pro-fibrotic pathways in human osteoarthritis fibroblasts 

      Vaamonde-García, Carlos; Malaise, Olivier; Charlier, Edith; Deroyer, Céline; Neuville, Sophie; Gillet, Philippe; Kurth, William; Meijide-Faílde, Rosa; Malaise, Michel G.; De Seny, Dominique (Elsevier, 2019-03-29)
      [Abstract] Abstract Background/aims: Synovial fibrosis is a pathological process that is observed in several musculoskeletal disorders and characterized by the excessive deposition of extracellular matrix, as well as cell ...

    • Effect of balneotherapy in sulfurous water on an in vivo murine model of osteoarthritis 

      Vaamonde-García, Carlos; Vela Anero, Ángela; Hermida Gómez, Tamara; Burguera, Elena F.; Filgueira-Fernández, P.; Goyanes, Noa; Blanco García, Francisco J; Meijide-Faílde, Rosa (Springer, 2019-11-01)
      [Abstract] Osteoarthritis (OA) is a chronic joint disease that results in progressive cartilage destruction and subsequently joint dysfunction. Growing evidence indicates beneficial impact of balneological interventions ...

    • Generation of human immortalized chondrocytes from osteoarthritic and healthy cartilage 

      Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Hermida-Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Vaamonde-García, Carlos; Díaz-Prado, Silvia (The British Editorial Society of Bone & Joint Surgery, 2023-01-17)
      [Abstract] Aims. After a few passages of in vitro culture, primary human articular chondrocytes undergo senescence and loss of their phenotype. Most of the available chondrocyte cell lines have been obtained from cartilage ...

    • In vitro study of the therapeutic potential of brown crude fucoidans in osteoarthritis treatment 

      Vaamonde-García, Carlos; Capelo Mera, Emma; Flórez-Fernández, Noelia; Torres, María Dolores; Rivas-Murias, Beatriz; Meijide-Faílde, Rosa; Blanco García, Francisco J; Domínguez, Herminia (MDPI, 2022-11-17)
      [Abstract] Osteoarthritis, one of the most common joint degenerative pathologies, still has no cure, and current treatments, such as nonsteroidal anti-inflammatory drugs, can cause serious adverse effects when taken for a ...

    • Intraarticular administration effect of hydrogen sulfide on an in vivo rat model of osteoarthritis 

      Vaamonde-García, Carlos; Burguera, Elena F.; Vela-Anero, Á.; Hermida Gómez, Tamara; Filgueira-Fernández, P.; Fernández-Rodríguez, Jennifer Adriana; Meijide-Faílde, Rosa; Blanco García, Francisco J (MDPI, 2020-10-08)
      [Abstract] Osteoarthritis (OA) is the most common articular chronic disease. However, its current treatment is limited and mostly symptomatic. Hydrogen sulfide (H2S) is an endogenous gas with recognized physiological ...

    • Long-term effects of hydrogen sulfide on the anabolic-catabolic balance of articular cartilage in vitro 

      Vela-Anero, Á.; Hermida Gómez, Tamara; Gato Calvo, Lucía; Vaamonde-García, Carlos; Díaz-Prado, Silvia; Meijide-Faílde, Rosa; Blanco García, Francisco J; Burguera, Elena F. (Elsevier, 2017-08-15)
      [Abstract] Healthy cartilage maintenance relies on an equilibrium among the anabolic and catabolic processes in chondrocytes. With the onset of osteoarthritis (OA), increased interleukin (IL)-1β levels induce an inhibition ...

    • Relevance of the extraction stage on the anti-inflammatory action of fucoidans 

      Flórez-Fernández, Noelia; Vaamonde-García, Carlos; Torres, María Dolores; Buján, Manuela; Muíños, Alexandra; Lamas-Vázquez, María J.; Meijide-Faílde, Rosa; Blanco García, Francisco J; Domínguez, Herminia (MDPI, 2023-03-01)
      [Abstract] The anti-inflammatory action of fucoidans is well known, based on both in vitro and some in vivo studies. The other biological properties of these compounds, their lack of toxicity, and the possibility of obtaining ...

    • Study of Fucoidans as Natural Biomolecules for Therapeutical Applications in Osteoarthritis 

      Vaamonde-García, Carlos; Flórez-Fernández, Noelia; Torres Pérez, María Dolores; Lamas Vázquez, María José; Blanco García, Francisco J; Domínguez, Herminia; Meijide-Faílde, Rosa (Elsevier, 2021-01-26)
      [Abstract] Osteoarthritis (OA) is the most prevalent articular chronic disease. Although, to date there is no cure for OA. Fucoidans, one of the main therapeutic components of brown algae, have emerged as promising molecules ...

    • Study of hydrogen sulfide biosynthesis in synovial tissue from diabetes-associated osteoarthritis and its influence on macrophage phenotype and abundance 

      Lendoiro-Cino, Natalia; Rodríguez-Coello, Arianna; Saborido, Anna; Burguera, Elena F.; Fernández-Rodríguez, Jennifer A.; Meijide-Faílde, Rosa; Blanco García, Francisco J; Vaamonde-García, Carlos (Springer, 2023-06-19)
      [Abstract] Type 2 diabetes (DB) is an independent risk factor for osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. Synovial macrophages from OA patients with DB ...

    • The mitochondrial inhibitor oligomycin induces an inflammatory response in the rat knee joint 

      Vaamonde-García, Carlos; Loureiro, Jesús; Valcárcel Ares, Marta Noa; Riveiro Naveira, Romina R.; Ramil-Gómez, Olalla; Hermida-Carballo, Laura; Centeno, Alberto; Meijide-Faílde, Rosa; Blanco García, Francisco J; López-Armada, María José (BioMed Central, 2017-06-12)
      [Abstract] Background. Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether ...

    • The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes–associated osteoarthritis 

      Vaamonde-García, Carlos; Courties, Alice; Pigenet, Audrey; Laiguillon, Marie-Charlotte; Sautet, Alain; Houard, Xavier; Kerdine-Römer, Saadia; Meijide-Faílde, Rosa; Berenbaum, Francis; Sellam, Jérémie (American Society for Biochemistry and Molecular Biology, 2017-07-06)
      [Asbtract] Epidemiological findings support the hypothesis that type 2 diabetes mellitus (T2DM) is a risk factor for osteoarthritis (OA). Moreover, OA cartilage from patients with T2DM exhibits a greater response to ...