Listar GI-TCMR - Artigos por autor "Hermida Gómez, Tamara"

Mostrando ítems 1-20 de 23

    • Alternative protocols to induce chondrogenic differentiation: transforming growth factor-β superfamily 

      Cicione, Claudia; Muiños Gómez, Emma; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Blanco García, Francisco J (Springer, 2014-09-10)
      [Abstract] Mesenchymal stem cells (MSCs) are an accepted candidate for cell-based therapy of multiple diseases. The interest in MSCs and their possible application in cell therapy have resulted in a better understanding ...

    • Bone marrow cells immunomagnetically selected for CD271+ antigen promote in vitro the repair of articular cartilage defects 

      Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Gimeno-Longas, María José; Muíños-López, Emma; Díaz-Prado, Silvia; De-Toro, Javier; Blanco García, Francisco J (Mary Ann Liebert, 2011-03-22)
      [Abstract] Objective: The purposes of this project were to quantify the cells expressing the mesenchymal stem cell (MSC) marker CD271 in synovial membranes from human osteoarthritic (OA) and healthy joints, and to determine ...

    • Cell and Tissue Transplant Strategies for Joint Lesions 

      Fuentes Boquete, Isaac Manuel; Arufe, M.C.; Díaz-Prado, Silvia; Hermida Gómez, Tamara; De-Toro, Javier; Blanco García, Francisco J (Bentham Open, 2008-07-11)
      [Abstract] Articular cartilage lesions that do not disrupt the integrity of subchondral bone are not capable of spontaneous repair. The asymptomatic nature of these lesions leads to articular cartilage degeneration and ...

    • Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes 

      Díaz-Prado, Silvia; Cicione, Claudia; Muiños-López, Emma; Hermida Gómez, Tamara; Oreiro, Natividad; Fernández-López, Carlos; Blanco García, Francisco J (BioMed Central, 2012-08-12)
      [Abstract] Background. Osteoarthritis (OA) is a multifactorial disease characterized by destruction of the articular cartilage due to environmental, mechanical and genetic components. The genetics of OA is complex and ...

    • Cryopreservation effect on proliferative and chondrogenic potential of human chondrocytes isolated from superficial and deep cartilage 

      Muíños López, Emma; Rendal Vázquez, María Esther; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Blanco García, Francisco J (Bentham Open, 2012-04-06)
      [Abstract] Objectives: To compare the proliferative and chondrogenic potential of fresh and frozen chondrocytes isolated from superficial and deep articular cartilage biopsies. Materials and Methodology: The study ...

    • Effect of balneotherapy in sulfurous water on an in vivo murine model of osteoarthritis 

      Vaamonde-García, Carlos; Vela Anero, Ángela; Hermida Gómez, Tamara; Burguera, Elena F.; Filgueira-Fernández, P.; Goyanes, Noa; Blanco García, Francisco J; Meijide-Faílde, Rosa (Springer, 2019-11-01)
      [Abstract] Osteoarthritis (OA) is a chronic joint disease that results in progressive cartilage destruction and subsequently joint dysfunction. Growing evidence indicates beneficial impact of balneological interventions ...

    • Effects of severe hypoxia on bone marrow mesenchymal stem cells differentiation potential 

      Cicione, Claudia; Muiños-López, Emma; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Blanco García, Francisco J (Hindawi, 2013-06-30)
      [Abstract] Background. The interests in mesenchymal stem cells (MSCs) and their application in cell therapy have resulted in a better understanding of the basic biology of these cells. Recently hypoxia has been indicated ...

    • Generation and Characterization of Human Induced Pluripotent Stem Cells (iPSCs) From Hand Osteoarthritis Patient-Derived Fibroblasts 

      Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Hermida Gómez, Tamara; Rodríguez-Fernández, Silvia; Oreiro, Natividad; De-Toro, Javier; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (Nature Research, 2020-03-06)
      [Abstract] Knowledge and research results about hand osteoarthritis (hOA) are limited due to the lack of samples and animal models of the disease. Here, we report the generation of two induced pluripotent stem cell ...

    • Generation of mesenchymal cell lines derived from aged donors 

      Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Castro Viñuelas, Rocío; Hermida Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (MDPI, 2021-10-01)
      [Abstract] Background: Mesenchymal stromal cells (MSCs) have the capacity for self-renewal and multi-differentiation, and for this reason they are considered a potential cellular source in regenerative medicine of cartilage ...

    • Human amniotic membrane as an alternative source of stem cells for regenerative medicine 

      Díaz-Prado, Silvia; Muiños-López, Emma; Hermida Gómez, Tamara; Cicione, Claudia; Rendal Vázquez, María Esther; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Elsevier, 2011-02-19)
      [Abstract] The human amniotic membrane (HAM) is a highly abundant and readily available tissue. This amniotic tissue has considerable advantageous characteristics to be considered as an attractive material in the field of ...

    • Human amniotic mesenchymal stromal cells as favorable source for cartilage repair 

      Muiños-López, Emma; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (Mary Ann Liebert, 2017-01-10)
      [Abstract] Introduction: Localized trauma-derived breakdown of the hyaline articular cartilage may progress toward osteoarthritis, a degenerative condition characterized by total loss of articular cartilage and joint ...

    • Human cartilage engineering in an in vitro repair model using collagen scaffolds and mesenchymal stromal cells 

      Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (Ivyspring, 2017-09-28)
      [Abstract] The purpose of this study was to investigate cartilage repair of in vitro lesion models using human bone marrow mesenchymal stromal cells (hBMSCs) with different collagen (Col) scaffolds. Lesions were made ...

    • Immortalizing mesenchymal stromal cells from aged donors while keeping their essential features 

      Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Hermida Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (Hindawi, 2020-06-16)
      [Abstract] Human bone marrow-derived mesenchymal stromal cells (MSCs) obtained from aged patients are prone to senesce and diminish their differentiation potential, therefore limiting their usefulness for osteochondral ...

    • Induced pluripotent stem cells for cartilage repair: current status and future perspectives 

      Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (AO Research Institute Davos, 2018-09-11)
      [Abstract] The establishment of cartilage regenerative medicine is an important clinical issue, but the search for cell sources able to restore cartilage integrity proves to be challenging. Human mesenchymal stromal cells ...

    • Intraarticular administration effect of hydrogen sulfide on an in vivo rat model of osteoarthritis 

      Vaamonde-García, Carlos; Burguera, Elena F.; Vela-Anero, Á.; Hermida Gómez, Tamara; Filgueira-Fernández, P.; Fernández-Rodríguez, Jennifer Adriana; Meijide-Faílde, Rosa; Blanco García, Francisco J (MDPI, 2020-10-08)
      [Abstract] Osteoarthritis (OA) is the most common articular chronic disease. However, its current treatment is limited and mostly symptomatic. Hydrogen sulfide (H2S) is an endogenous gas with recognized physiological ...

    • Isolation and characterization of mesenchymal stem cells from human amniotic membrane 

      Díaz-Prado, Silvia; Muíños-López, Emma; Hermida Gómez, Tamara; Rendal Vázquez, María Esther; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Mary Ann Liebert, 2011-01-04)
      [Abstract] Introduction: The human amniotic membrane is a highly abundant and readily available tissue that may be useful for regenerative medicine and cell therapy. Aim: To compare two previously published protocols for ...

    • Long-term effects of hydrogen sulfide on the anabolic-catabolic balance of articular cartilage in vitro 

      Vela-Anero, Á.; Hermida Gómez, Tamara; Gato Calvo, Lucía; Vaamonde-García, Carlos; Díaz-Prado, Silvia; Meijide-Faílde, Rosa; Blanco García, Francisco J; Burguera, Elena F. (Elsevier, 2017-08-15)
      [Abstract] Healthy cartilage maintenance relies on an equilibrium among the anabolic and catabolic processes in chondrocytes. With the onset of osteoarthritis (OA), increased interleukin (IL)-1β levels induce an inhibition ...

    • Molecular profile and cellular characterization of human bone marrow mesenchymal stem cells: donor influence on chondrogenesis 

      Cicione, Claudia; Díaz-Prado, Silvia; Muiños-López, Emma; Hermida Gómez, Tamara; Blanco García, Francisco J (Elsevier, 2010)
      [Abstract] Background. The use of autologous or allogenic stem cells has recently been suggested as an alternative therapeutic approach for treatment of cartilage defects. Bone marrow mesenchymal stem cells (BM-MSCs) are ...

    • Multilineage differentiation potential of cells isolated from the human amniotic membrane 

      Díaz-Prado, Silvia; Muiños-López, Emma; Hermida Gómez, Tamara; Rendal Vázquez, María Esther; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Wiley, 2010-11-01)
      [Abstract] The human amniotic membrane (HAM) contains two cell types from different embryological origins. Human amnion epithelial cells (hAECs) are derived from the embryonic ectoderm, while human amnion mesenchymal stromal ...

    • Ovine mesenchymal stromal cells: morphologic, phenotypic and functional characterization for osteochondral tissue engineering 

      Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Hermida Gómez, Tamara; Fernández Vázquez, Tania; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Díaz-Prado, Silvia; Blanco García, Francisco J (PLoS ONE, 2017-01-31)
      [Abstract] Introduction. Knowledge of ovine mesenchymal stromal cells (oMSCs) is currently expanding. Tissue engineering combining scaffolding with oMSCs provides promising therapies for the treatment of osteochondral ...