• Biology of BMP signalling and cancer 

      Blanco, Moisés; Bolós Fernández, Victoria; Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Díaz-Prado, Silvia; Grande Pulido, Enrique (Springer, 2009)
      [Abstract] In recent years, it has been proposed that tumours are not homogeneous but composed of several cellular types like normal tissues. A cellular subtype, which is though to be the origin of tumours as well as their ...
    • Evaluation of Plakophilin-3 mRNA as a biomarker for detection of circulating tumor cells in gastrointestinal cancer patients 

      Valladares-Ayerbes, Manuel; Díaz-Prado, Silvia; Reboredo, Margarita; Medina, Vanessa; Lorenzo-Patiño, María J.; Iglesias-Díaz, Pilar; Haz, Mar; Pértega-Díaz, Sonia; Santamarina, Isabel; Blanco, Moisés; Quindós-Varela, María; Figueroa, Angélica; Antón-Aparicio, Luis M. (American Association for Cancer Research, 2010-05-25)
      [Abstract] Background: This study aims to assess Plakophilin-3 (PKP3) as a surrogate biomarker of circulating tumor cells in patients with gastrointestinal cancer. Methods: The primary aim is to estimate the diagnostic ...
    • Evaluation of the adenocarcinoma-associated gene AGR2 and the intestinal stem cell marker LGR5 as biomarkers in colorectal cancer 

      Valladares-Ayerbes, Manuel; Blanco, Moisés; Reboredo, Margarita; Lorenzo-Patiño, María J.; Iglesias-Díaz, Pilar; Haz, Mar; Díaz-Prado, Silvia; Medina, Vanessa; Santamarina, Isabel; Pértega-Díaz, Sonia; Figueroa, Angélica; Antón-Aparicio, Luis M. (MDPI, 2012-04-05)
      [Abstract] We aim to estimate the diagnostic performances of anterior gradient homolog-2 (AGR2) and Leucine-rich repeat-containing-G-protein-coupled receptor 5 (LGR5) in peripheral blood (PB) as mRNA biomarkers in colorectal ...
    • Expression of Wnt gene family and frizzled receptors in head and neck squamous cell carcinomas 

      Díaz-Prado, Silvia; Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Blanco, Moisés; López Cedrún, José Luis; Sironvalle Soliva, Sheila; Valladares-Ayerbes, Manuel; García Campelo, Rosario; Antón-Aparicio, Luis M. (Spirnger, 2009)
      [Abstract] Genes of the Wnt and Frizzled class, expressed in HNSCC tissue and cell lines, have an established role in cell morphogenesis and differentiation, and also they have oncogenic properties. We studied Wnt and Fz ...
    • Hedgehog signalling as a target in cancer stem cells 

      Medina Villaamil, Vanessa; Blanco, Moisés; Díaz-Prado, Silvia; Espada, Jesús (Spirnger, 2009)
      [Abstract] Hedgehog (Hh) is one of the most important signalling pathways. Together with the Wnt, TGF-β/BMP and Notch pathways, it is involved in both embryonic development and adult tissue homeostasis. This is because Hh ...