Transcranial static magnetic field stimulation of the human motor cortex
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Transcranial static magnetic field stimulation of the human motor cortexAuthor(s)
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2001-08-01Citation
Oliviero A, Mordillo-Mateos L, Arias P, Panyavin I, Foffani G, Aguilar J. Transcranial static magnetic field stimulation of the human motor cortex. J Physiol. 2011;589(20):4949-4958.
Abstract
[Abstract] The aim of the present study was to investigate in healthy humans the possibility of a
non-invasive modulation of motor cortex excitability by the application of static magnetic fields
through the scalp. Static magnetic fields were obtained by using cylindrical NdFeB magnets. We
performed four sets of experiments. In Experiment 1, we recorded motor potentials evoked by
single-pulse transcranial magnetic stimulation (TMS) of the motor cortex before and after 10min
of transcranial static magnetic field stimulation (tSMS) in conscious subjects. We observed an
average reduction of motor cortex excitability of up to 25%, as revealed by TMS, which lasted for
severalminutes after the end of tSMS, andwas dose dependent (intensity of the magnetic field) but
not polarity dependent. In Experiment 2, we confirmed the reduction of motor cortex excitability
induced by tSMS using a double-blind sham-controlled design. In Experiment 3, we investigated
the duration of tSMS that was necessary to modulate motor cortex excitability. We found that
10 min of tSMS (compared to 1min and 5 min) were necessary to induce significant effects. In
Experiment 4, we used transcranial electric stimulation (TES) to establish that the tSMS-induced
reduction ofmotor cortex excitability was not due to corticospinal axon and/or spinal excitability,
but specifically involved intracortical networks. These results suggest that tSMS using small static
magnets may be a promising tool to modulate cerebral excitability in a non-invasive, painless,
and reversible way.
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This is the peer reviewed version of the following article, which has been published in final form at Wiley Online Library. This article may be used for non-commercial purposes in accordance with Wiley Terms and Copnditions for self-archiving.