Bursting thalamic responses in awake monkey contribute to visual detection and are modulated by corticofugal feedback
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Bursting thalamic responses in awake monkey contribute to visual detection and are modulated by corticofugal feedbackFecha
2014-05-30Cita bibliográfica
Ortuño T, Grieve KL, Cao R, Cudeiro J, Rivadulla C. Bursting thalamic responses in awake monkey contribute to visual detection and are modulated by corticofugal feedback. Front Behav Neurosci. 2014;8:198.
Resumen
[Abstract] The lateral geniculate nucleus is the gateway for visual information en route to the visual
cortex. Neural activity is characterized by the existence of two firing modes: burst and
tonic. Originally associated with sleep, bursts have now been postulated to be a part of
the normal visual response, structured to increase the probability of cortical activation,
able to act as a “wake-up” call to the cortex. We investigated a potential role for burst
in the detection of novel stimuli by recording neuronal activity in the lateral geniculate
nucleus (LGN) of behaving monkeys during a visual detection task. Our results show that
bursts are often the neuron’s first response, and are more numerous in the response to
attended target stimuli than to unattended distractor stimuli. Bursts are indicators of the
task novelty, as repetition decreased bursting. Because the primary visual cortex is the
major modulatory input to the LGN, we compared the results obtained in control conditions
with those observed when cortical activity was reduced by TMS. This cortical deactivation
reduced visual response related bursting by 90%. These results highlight a novel role for
the thalamus, able to code higher order image attributes as important as novelty early in
the thalamo-cortical conversation.
Palabras clave
Attention
Burst
LGN
Thalamo-cortical
Visual
Burst
LGN
Thalamo-cortical
Visual
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