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Toxo: A Library for Calculating Penetrance Tables of High-Order Epistasis Models
(BioMed Central Ltd., 2020-04-09)
[Abstract]
Background
Epistasis is defined as the interaction between different genes when expressing a specific phenotype. The most common way to characterize an epistatic relationship is using a penetrance table, which ...
Evaluation of Existing Methods for High-Order Epistasis Detection
(Institute of Electrical and Electronics Engineers, 2020-10-15)
[Abstract]
Finding epistatic interactions among loci when expressing a phenotype is a widely employed strategy to understand the genetic architecture of complex traits in GWAS. The abundance of methods dedicated to the ...
Parallel definition of tear film maps on distributed-memory clusters for the support of dry eye diagnosis
(Elsevier Ireland Ltd., 2017)
[Abstract] Background and objectives
The analysis of the interference patterns on the tear film lipid layer is a useful clinical test to diagnose dry eye syndrome. This task can be automated with a high degree of accuracy ...
A 2D algorithm with asymmetric workload for the UPC conjugate gradient method
(Springer New York LLC, 2014)
[Abstract] This paper examines four different strategies, each one with its own data distribution, for implementing the parallel conjugate gradient (CG) method and how they impact communication and overall performance. ...
Fast search of third-order epistatic interactions on CPU and GPU clusters
(Sage Publications Ltd., 2019-05-27)
[Abstract]
Genome-Wide Association Studies (GWASs), analyses that try to find a link between a given phenotype (such as a disease) and genetic markers, have been growing in popularity in the recent years. Relations between ...
PyToxo: a Python tool for calculating penetrance tables of high-order epistasis models
(BMC, 2022)
[Abstract] Background
Epistasis is the interaction between different genes when expressing a certain phenotype. If epistasis involves more than two loci it is called high-order epistasis. High-order epistasis is an area ...
A SIMD Algorithm for the Detection of Epistatic Interactions of Any Order
(Elsevier, 2022)
[Abstract] Epistasis is a phenomenon in which a phenotype outcome is determined by the interaction of genetic variation at two or more loci and it cannot be attributed to the additive combination of effects corresponding ...
Fiuncho: a program for any-order epistasis detection in CPU clusters
(Springer, 2022)
[Abstract]: Epistasis can be defined as the statistical interaction of genes during the expression of a phenotype. It is believed that it plays a fundamental role in gene expression, as individual genetic variants have ...
PARamrfinder: detecting allele-specific DNA methylation on multicore clusters
(Springer, 2024-01)
[Abstract]: The discovery of Allele-Specific Methylation (ASM) is an important research field in biology as it regulates genomic imprinting, which has been identified as the cause of some genetic diseases. Nevertheless, ...
Automatic mapping of parallel applications on multicore architectures using the Servet benchmark suite
(Pergamon Press, 2012-03)
[Abstract] Servet is a suite of benchmarks focused on detecting a set of parameters with high influence on the overall performance of multicore systems. These parameters can be used for autotuning codes to increase their ...