Listar por autor "Venkatesan, Jagadeesh Kumar"
Mostrando ítems 1-5 de 5
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Biomaterial-Assisted Gene Therapy for Translational Approaches to Treat Musculoskeletal Disorders
Venkatesan, Jagadeesh Kumar; Rey-Rico, Ana; Meng, Weikun; Cai, Xiaoyu; Pons, Françoise; Lebeau, Luc; Migonney, Véronique; Madry, Henning; Cucchiarini, Magali (Elsevier, 2020-12-28)[Abstract] Biomaterial-assisted gene therapy is a promising strategy for the treatment of various musculoskeletal disorders such as those concerning the articular cartilage, bones, tendons and ligaments, and meniscus as ... -
Current trends in viral gene therapy for human orthopaedic regenerative medicine
Venkatesan, Jagadeesh Kumar; Rey-Rico, Ana; Cucchiarini, Magali (Springer, 2019-02-21)[Abstract] Background: Viral vector-based therapeutic gene therapy is a potent strategy to enhance the intrinsic reparative abilities of human orthopaedic tissues. However, clinical application of viral gene transfer remains ... -
Remodeling of human osteochondral defects via rAAV-mediated co-overexpression of TGF-β and IGF-I from implanted human bone marrow-derived mesenchymal stromal cells
Morscheid, Stephanie; Venkatesan, Jagadeesh Kumar; Rey-Rico, Ana; Schmitt, Gertrud; Cucchiarini, Magali (MDPI, 2019-08-28)[Abstract] The application of chondrogenic gene sequences to human bone marrow-derived mesenchymal stromal cells (hMSCs) is an attractive strategy to activate the reparative activities of these cells as a means to enhance ... -
Scaffold-Mediated Gene Delivery for Osteochondral Repair
Madry, Henning; Venkatesan, Jagadeesh Kumar; Carballo-Pedrares, Natalia; Rey-Rico, Ana; Cucchiarini, Magali (MDPI, 2020-09-29)[Abstract] Osteochondral defects involve both the articular cartilage and the underlying subchondral bone. If left untreated, they may lead to osteoarthritis. Advanced biomaterial-guided delivery of gene vectors has ... -
Therapeutic effects of rAAV-mediated concomittant gene transfer and overexpression of TGF-β and IGF-I on the chondrogenesis of human bone-marrow-derived mesenchymal stem cells
Morscheid, Stephanie; Rey-Rico, Ana; Schmitt, Gertrud; Madry, Henning; Cucchiarini, Magali; Venkatesan, Jagadeesh Kumar (MDPI, 2019-05-27)[Abstract] Application of chondroreparative gene vectors in cartilage defects is a powerful approach to directly stimulate the regenerative activities of bone-marrow-derived mesenchymal stem cells (MSCs) that repopulate ...