• Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis 

      García-Galiano, David; Pineda, Rafael; Ilhan, Tuncay; Castellano, Juan Manuel; Ruiz-Pino, Francisco; Sánchez-Garrido, Miguel Ángel; Vázquez, M.J.; Sangiao-Alvarellos, Susana; Romero-Ruiz, Antonio; Pinilla, Leonor; García-Diéguez, Carlos; Gaytán, Francisco; Tena-Sempere, Manuel (Oxford Academic, 2012-02-14)
      [Abstract] Nesfatin-1, product of the precursor NEFA/nucleobindin2 (NUCB2), was initially identified as anorectic hypothalamic neuropeptide, acting in a leptin-independent manner. In addition to its central role in the ...
    • Deregulation of miR-324/KISS1/kisspeptin in early ectopic pregnancy: mechanistic findings with clinical and diagnostic implications 

      Romero-Ruiz, Antonio; Avendaño, María S.; Domínguez, Francisco; Lozoya, Teresa; Molina-Abril, Helena; Sangiao-Alvarellos, Susana; Gurrea, Marta; Lara-Chica, Maribel; Fernández-Sánchez, Manuel; Torres-Jiménez, Encarnación; Perdices-López, Cecilia; Abbara, Ali; Steffani, Liliana; Calzado, Marco A.; Dhilo, Waljit S.; Pellicer, Antonio; Tena-Sempere, Manuel (Elsevier, 2019-05)
      [Abstract] BACKGROUND: Ectopic pregnancy is a life-threatening condition for which novel screening tools that would enable early accurate diagnosis would improve clinical outcomes. Kisspeptins, encoded by KISS1, play ...
    • Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism 

      Gaytán, Francisco; Sangiao-Alvarellos, Susana; Manfredi-Lozano, María; García-Galiano, David; Ruiz-Pino, Francisco; Romero-Ruiz, Antonio; León, Silvia; Morales, Concepción; Cordido, Fernando; Pinilla, Leonor; Tena-Sempere, Manuel (Endocrine Society, 2013-01-21)
      [Abstract] Lin28 (also termed Lin28a) and Lin28b are related RNA-binding proteins, involved in the control of microRNA synthesis, especially of the let-7 family, with putative functions in early (embryo) development. ...
    • The Lin28/Let-7 system in early human embryonic tissue and ectopic pregnancy 

      Lozoya, Teresa; Domínguez, Francisco; Romero-Ruiz, Antonio; Steffani, Liliana; Martínez, Sebastián; Monterde, Mercedes; Ferri, Blanca; Núñez, María José; Romero-Espinós, Ainhoa; Zamora, Omar; Guerra, Marta; Sangiao-Alvarellos, Susana; Vega, Olivia; Simón, Carlos; Pellicer, Antonio; Tena-Sempere, Manuel (PLoS One, 2014-01-31)
      [Abstract] Our objective was to determine the expression of the elements of the Lin28/Let-7 system, and related microRNAs (miRNAs), in early stages of human placentation and ectopic pregnancy, as a means to assess the ...