Listar por autor "Peinador, Carlos"
Mostrando ítems 1-16 de 16
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Amino Acid–Viologen Hybrids: Synthesis, Cucurbituril Host–Guest Chemistry, and Implementation on the Production of Peptides
Barravecchia Prado, Liliana Inés; Neira, Iago; Pazos, Elena; Peinador, Carlos; García, Marcos D. (American Chemical Society, 2021-12-10)[Abstract] We present herein the development of a series of viologen–amino acid hybrids, obtained in good yields either by successive alkylations of 4,4′-bipyridine, or by Zincke reactions followed by a second alkylation ... -
Aqueous Three-Component Self-Assembly of a Pseudo[1]rotaxane Using Hydrazone Bonds
Cortón, Pablo; Fernández Labandeira, Natalia; Díaz Abellás, Mauro; Peinador, Carlos; Pazos, Elena; Blanco-Gómez, Arturo; García, Marcos D. (American Chemical Society, 2023-04-28)[Abstract] We present herein the synthesis of a new polycationic pseudo[1]rotaxane, self-assembled in excellent yield through hydrazone bonds in aqueous media of three different aldehyde and hydrazine building blocks. A ... -
CB[7]- and CB[8]-Based [2]-(Pseudo)rotaxanes with Triphenylphosphonium-Capped Threads: Serendipitous Discovery of a New High-Affinity Binding Motif
Neira, Iago; Peinador, Carlos; García, Marcos D. (American Chemical Society, 2022-05-06)[Abstract] The synthesis of new triphenylphosphonium-capped cucurbit[7]uril (CB[7])- and cucurbit[8]uril (CB[8])-based [2]rotaxanes was achieved by a simultaneous threading-capping strategy. While the use of CB[7] produced ... -
Controlled Binding of Organic Guests by Stimuli-Responsive Macrocycles
Blanco-Gómez, Arturo; Cortón, Pablo; Barravecchia Prado, Liliana Inés; Neira, Iago; Pazos, Elena; Peinador, Carlos; García, Marcos D. (Royal Society of Chemistry, 2020-05-12)[Abstract] Synthetic supramolecular chemistry pursues not only the construction of new matter, but also control over its inherently dynamic behaviour. In this context, classic host–guest chemistry, based on the development ... -
Cucurbit[8]uril (CB[8])-Based Supramolecular Switches
Pazos, Elena; Novo, Paula; Peinador, Carlos; Kaifer, Angel; García, Marcos D. (Wiley, 2018-07-06)[Abstract] The use of cucurbit[8]uril as a molecular host has emerged in the chemical literature as a reliable strategy for the creation of dynamic chemical systems, owing to its ability to form homo- and heteroternary ... -
Host-Guest Stimuli-Responsive Click Chemistry
Blanco-Gómez, Arturo; Díaz Abellás, Mauro; Montes de Oca Estrada, Iván; Peinador, Carlos; Pazos, Elena; García, Marcos D. (Wiley, 2024-05-10)[Abstract] Click chemistry has reached its maturity as the weapon of choice for the irreversible ligation of molecular fragments, with over 20 years of research resulting in the development or improvement of highly efficient ... -
Reversible Control of DNA Binding with Cucurbit[8]uril-Induced Supramolecular 4,4′-Bipyridinium–Peptide Dimers
Novo, Paula; García, Marcos D.; Peinador, Carlos; Pazos, Elena (American Chemical Society, 2021-03-08)[Abstract] Many cellular processes in living organisms are regulated by complex regulatory networks, built from noncovalent interactions between relatively few proteins that perform their functions by switching between ... -
Self-Assembled Peptide–Inorganic Nanoparticle Superstructures: From Component Design to Applications
Pigliacelli, Claudia; Sánchez-Fernández, Rosalía; García, Marcos D.; Peinador, Carlos; Pazos, Elena (Royal Society of Chemistry, 2020-06-04)[Abstract] Peptides have become excellent platforms for the design of peptide–nanoparticle hybrid superstructures, owing to their self-assembly and binding/recognition capabilities. Morover, peptide sequences can be encoded ... -
Solid-Phase Zincke Reaction for the Synthesis of Peptide-4,4′-bipyridinium Conjugates
Cortón, Pablo; Novo, Paula; López Sobrado, Vanesa; García, Marcos D.; Peinador, Carlos; Pazos, Elena (Thieme, 2020-02)[Abstract] We present herein the development of a new synthetic strategy for the conjugation of 4,4′-bipyridinium derivatives into peptide scaffolds. The methodology, based on the development of a solid-phase version of ... -
Stimuli-responsive metal-directed self-assembly of a ring-in-ring complex
Alvariño Bouza, Cristina; Platas-Iglesias, Carlos; Blanco, Víctor; García, Marcos D.; Peinador, Carlos; Quintela López, José María (Royal Society of Chemistry, 2016-06-06)[Abstract] Concentration, temperature and/or solvent polarity control the speciation on the metal-directed self-assembly of a ditopic pyridyl ligand L with cis-protected Pd(II) metal centers. This results into a controllable ... -
Subcellular duplex DNA and G‐quadruplex interaction profiling of a hexagonal PtII metallacycle
Domarco, Olaya; Kieler, Claudia; Pirker, Christine; Dinhof, Carina; Englinger, Bernhard; Reisecker, Johannes M.; Timelthaler, Gerald; García, Marcos D.; Peinador, Carlos; Keppler, Bernhard K.; Berger, Walter; Terenzi, Alessio (Wiley, 2019-04-19)[Abstract] Metal‐driven self‐assembly afforded a multitude of fascinating supramolecular coordination complexes (SCCs) with applications as catalysts, host–guest, and stimuli‐responsive systems. However, the interest in ... -
The Red Cage: Implementation of pH-Responsiveness Within a Macrobicyclic Pyridinium-Based Molecular Host
Cortón, Pablo; Wang, Hongye; Neira, Iago; Blanco-Gómez, Arturo; Pazos, Elena; Peinador, Carlos; Li, Hao; García, Marcos D. (Royal Society of Chemistry, 2021-11-09)[Abstract] We present herein the implementation of pH-responsiveness into a new polycationic macrobicyclic structure, namely what we have termed the “red cage”. The hydrolytically-stable cryptand-like compound has been ... -
Thinking Outside the Blue Box: From Molecular to Supramolecular PH-Responsiveness
Blanco-Gómez, Arturo; Neira, Iago; Barriada, José Luis; Melle-Franco, Manuel; Peinador, Carlos; García, Marcos D. (Royal Society of Chemistry, 2019-10-23)[Abstract] We present herein the development of a new polycationic cyclophane: the “red box”, second in a series of hydrazone-based analogues of the well-known organic receptor cyclobis(paraquat-p-phenylene)cyclophane ... -
Thinking Outside the Blue Box: Induced Fit within a Unique Self-Assembled Polycationic Cyclophane
Blanco-Gómez, Arturo; Fernández-Blanco, Ángel; Blanco, Víctor; Rodríguez, Jaime; Peinador, Carlos; García, Marcos D. (ACS, 2019-02-07)[Abstract] We present herein the development of a new polycationic molecular receptor, inspired by the ubiquitous cyclobis(paraquat-p-phenylene)cyclophane (“blue box”). Our analogue, the “white box”, has been easily ... -
Vermellogens and the Development of CB[8]-Based Supramolecular Switches Using pH-Responsive and Non-Toxic Viologen Analogues
Barravecchia Prado, Liliana Inés; Blanco-Gómez, Arturo; Neira, Iago; Skackauskaite, Raminta; Vila García, Alejandro; Rey-Rico, Ana; Peinador, Carlos; García, Marcos D. (ACS, 2022-10-07)[Abstract] We present herein the “vermellogens”, a new class of pH-responsive viologen analogues, which replace the direct linking between para-substituted pyridinium moieties within those by a hydrazone functional group. ...
