Listar por autor "Pazos, Elena"
Mostrando ítems 1-8 de 8
-
Affinity-Controlled Capture and Release of Engineered Monoclonal Antibodies by Macroporous Dextran Hydrogels Using Coiled-Coil Interactions [Report]
Baniahmad, Seyed Farzad; Oliverio, Romane; Obregón Gómez, Inés; Robert, Alma; Lenferink, Anne; Pazos, Elena; Virgilio, Nick; Banquy, Xavier; De Crescenzo, Gregory; Durocher, Yves (Taylor & Francis, 2023-06-10)[Abstract] Long-term delivery is a successful strategy used to reduce the adverse effects of monoclonal antibody (mAb)-based treatments. Macroporous hydrogels and affinity-based strategies have shown promising results in ... -
Amino Acid–Viologen Hybrids: Synthesis, Cucurbituril Host–Guest Chemistry, and Implementation on the Production of Peptides
Barravecchia Prado, Liliana Inés; Neira, Iago; Pazos, Elena; Peinador, Carlos; García, Marcos D. (American Chemical Society, 2021-12-10)[Abstract] We present herein the development of a series of viologen–amino acid hybrids, obtained in good yields either by successive alkylations of 4,4′-bipyridine, or by Zincke reactions followed by a second alkylation ... -
Controlled Binding of Organic Guests by Stimuli-Responsive Macrocycles
Blanco-Gómez, Arturo; Cortón, Pablo; Barravecchia Prado, Liliana Inés; Neira, Iago; Pazos, Elena; Peinador, Carlos; García, Marcos D. (Royal Society of Chemistry, 2020-05-12)[Abstract] Synthetic supramolecular chemistry pursues not only the construction of new matter, but also control over its inherently dynamic behaviour. In this context, classic host–guest chemistry, based on the development ... -
Cucurbit[8]uril (CB[8])-Based Supramolecular Switches
Pazos, Elena; Novo, Paula; Peinador, Carlos; Kaifer, Angel; García, Marcos D. (Wiley, 2018-07-06)[Abstract] The use of cucurbit[8]uril as a molecular host has emerged in the chemical literature as a reliable strategy for the creation of dynamic chemical systems, owing to its ability to form homo- and heteroternary ... -
Probing Tyrosine Nitration with a Small TbIII-Metallopeptide
Sánchez-Fernández, Rosalía; Sánchez-Temprano, Agustín; Esteban-Gómez, David; Pazos, Elena (Wiley, 2023-06-06)[Abstract] Tyrosine nitration, a post-translational modification (PTM) that takes place under nitrosative stress conditions, occurs through a non-enzymatic peroxynitrite-mediated reaction. Although protein nitration has ... -
Reversible Control of DNA Binding with Cucurbit[8]uril-Induced Supramolecular 4,4′-Bipyridinium–Peptide Dimers
Novo, Paula; García, Marcos D.; Peinador, Carlos; Pazos, Elena (American Chemical Society, 2021-03-08)[Abstract] Many cellular processes in living organisms are regulated by complex regulatory networks, built from noncovalent interactions between relatively few proteins that perform their functions by switching between ... -
Self-Assembled Peptide–Inorganic Nanoparticle Superstructures: From Component Design to Applications
Pigliacelli, Claudia; Sánchez-Fernández, Rosalía; García, Marcos D.; Peinador, Carlos; Pazos, Elena (Royal Society of Chemistry, 2020-06-04)[Abstract] Peptides have become excellent platforms for the design of peptide–nanoparticle hybrid superstructures, owing to their self-assembly and binding/recognition capabilities. Morover, peptide sequences can be encoded ... -
The Red Cage: Implementation of pH-Responsiveness Within a Macrobicyclic Pyridinium-Based Molecular Host
Cortón, Pablo; Wang, Hongye; Neira, Iago; Blanco-Gómez, Arturo; Pazos, Elena; Peinador, Carlos; Li, Hao; García, Marcos D. (Royal Society of Chemistry, 2021-11-09)[Abstract] We present herein the implementation of pH-responsiveness into a new polycationic macrobicyclic structure, namely what we have termed the “red cage”. The hydrolytically-stable cryptand-like compound has been ...