Listar por autor "Lenis Rojas, Óscar"

Mostrando ítems 1-6 de 6

    • Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp. 

      Pech-Puch, Dawrin; Grilo, Diana; Calva Pérez, Susana Eunice; Pedras, Andreia; Villegas-Hernández, Harold; Guillén-Hernández, Sergio; Díaz-Gamboa, Raúl E.; Forero, Abel M.; Rodríguez, Jaime; Lenis Rojas, Óscar; Jiménez, Carlos; Pimentel, Catarina (MDPI, 2023-01-06)
      [Abstract] Invasive fungal infections represent a global health threat. They are associated with high mortality and morbidity rates, partly due to the ineffectiveness of the available antifungal agents. The rampant increase ...

    • Diseño y estudio de compuestos de rutenio con actividad biológica 

      Lenis Rojas, Óscar (2017)
      [Resumo] O presente proxecto aborda a síntese e caracterización estructural de novos compostos de coordinación mono e polinucleares de rutenio derivados de bipiridina e novos compostos organometálicos mononucleares de ...

    • Evaluation of the in Vitro and in Vivo Efficacy of Ruthenium Polypyridyl Compounds Against Breast Cancer 

      Lenis Rojas, Óscar; Roma-Rodrigues, Catarina; Fernandes, Alexandra R.; Carvalho, Andreia; Cordeiro, Sandra; Guerra-Varela, Jorge; Sánchez, Laura; Vázquez, Digna; López-Torres, Margarita; Fernández, Alberto; Fernández, Jesús J. (MDPI, 2021-08-18)
      [Abstract] The clinical success of cisplatin, carboplatin, and oxaliplatin has sparked the interest of medicinal inorganic chemistry to synthesize and study compounds with non-platinum metal centers. Despite Ru(II)–polypyridyl ...

    • Half-Sandwich Ru(p-cymene) Compounds with Diphosphanes: In Vitro and In Vivo Evaluation As Potential Anticancer Metallodrugs 

      Lenis Rojas, Óscar; Robalo, M. Paula; Tomaz, A. I.; Fernandes, Alexandra; Roma-Rodrigues, Catarina; Teixeira, Ricardo Gonçalves; Marques, Fernanda; Folgueira, Mónica; Yáñez, Julián; Alba-González, Anabel; Salamini-Montemurri, Martín; Pech-Puch, Dawrin; Vázquez, Digna; López-Torres, Margarita; Fernández, Alberto; Fernández Sánchez, Jesús José (American Chemical Society (ACS), 2021-02-11)
      [Abstract] Ruthenium(II) complexes are currently considered attractive alternatives to the widely used platinum-based drugs. We present herein the synthesis and characterization of half-sandwich ruthenium compounds formulated ...

    • Marine Natural Products from the Yucatan Peninsula 

      Pech-Puch, Dawrin; Pérez Povedano, Mar Anabel; Lenis Rojas, Óscar; Rodríguez, Jaime; Jiménez, Carlos (MDPI AG, 2020-01-16)
      [Abstract] Mexico is one of the three areas of the world with the greatest terrestrial and cultural biological diversity. The diversity of Mexican medicinal flora has been studied for a long time and several bioactive ...

    • RuII(p-cymene) Compounds as Effective and Selective Anticancer Candidates with No Toxicity in Vivo 

      Lenis Rojas, Óscar; Robalo, M. Paula; Tomaz, A. I.; Carvalho, Andreia; Fernandes, Alexandra; Marques, Fernanda; Folgueira, Mónica; Yáñez, Julián; Vázquez, Digna; López-Torres, Margarita; Fernández, Alberto; Fernández Sánchez, Jesús José (American Chemical Society (ACS), 2018-10-19)
      [Abstract] Ruthenium(II) complexes are currently considered a viable alternative to the widely used platinum complexes as efficient anticancer agents. We herein present the synthesis and characterization of half-sandwich ...