• Baseline clinical characteristics of predicted structural and pain progressors in the IMI-APPROACH knee OA cohort 

      van Helvoort, Eefje M.; Ladel, Christoph H.; Mastbergen, Simon; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Bacardit, Jaume; Widera, Pawel; Welsing, Paco M.J.; Lafeber, Floris (BMJ, 2021-08-23)
      [Abstract] Objectives: To describe the relations between baseline clinical characteristics of the Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) participants and their predicted ...
    • Can gait patterns be explained by joint structure in people with and without radiographic knee osteoarthritis?: data from the IMI-APPROACH cohort 

      Jansen, Mylène P.; Hodgins, Diana; Mastbergen, Simon C.; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Eckstein, Felix; Roemer, Frank W.; Wirt, Wolfgang (Springer Nature, 2024-03-27)
      [Abstract] Objective: To determine the association between joint structure and gait in patients with knee osteoarthritis (OA). Methods: IMI-APPROACH recruited 297 clinical knee OA patients. Gait data was collected ...
    • Cohort profile: the Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers 

      van Helvoort, Eefje M.; van Spil, Willem E.; Jansen, Mylène P.; Welsing, Paco M.J.; Kloppenburg, Margreet; Loef, Marieke; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Bacardit, Jaume; Ladel, Christoph H.; Loughlin, John; Bay-Jensen, Anne C.; Mobasheri, Ali; Larkin, Jonathan; Boere, Janneke; Weinans, Harrie H.; Lalande, Agnes; Marijnissen, Anne C.A.; Lafeber, Floris (BMJ, 2020-07-28)
      [Abstract] Purpose The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (APPROACH) consortium intends to prospectively describe in detail, preselected patients with knee osteoarthritis (OA), using ...
    • Core Outcome Measurement Instrument Selection for Physical Function in Hand Osteoarthritis Using the OMERACT Filter 2.1 Process 

      Kroon, Féline P.B.; van der Heijde, Désirée; Maxwell, Lara J.; Beaton, Dorcas E.; Abishek, Abishek; Berenbaum, Francis; Blanco García, Francisco J; Conaghan, Philip G.; Dziedzic, Krysia; Hill, Catherine L.; Haugen, Ida K.; Ishimori, Mariko; Ritschl, Valentin; Stamm, Tanja A.; Wittoek, Ruth; Kopplenburg, Margreet (Elsevier, 2021-12)
      [Abstract] Objective: Physical function is one of the Outcome Measures in Rheumatology (OMERACT) core outcome domains for hand osteoarthritis studies. Our aim was to select appropriate instrument(s) to measure this domain, ...
    • Development and validation of a machine learning-supported strategy of patient selection for osteoarthritis clinical trials: the IMI-APPROACH study 

      Widera, Pawel; Welsing, Paco M.J.; Danso, Samuel O.; Peelen, Sjaak; Kloppenburg, Margreet; Loef, Marieke; Marijnissen, Anne C.; van Helvoort, Eefje M.; Blanco García, Francico J; Magalhaes, Joana; Berenbaum, Francis; Haugen, Ida K.; Bay-Jensen, Anne-C.; Mobasheri, Ali; Ladel, Christoph; Loughlin, John; Lafeber, Floris P.J.G.; Lalande, Agnes; Larkin, Jonathan; Weinans, Harrie; Bacardit, Jaume (Elsevier, 2023-12)
      [Abstract] Objectives. To efficiently assess the disease-modifying potential of new osteoarthritis treatments, clinical trials need progression-enriched patient populations. To assess whether the application of machine ...
    • Exploring the differences between radiographic joint space width and MRI cartilage thickness changes using data from the IMI-APPROACH cohort 

      Jansen, Mylène P.; Roemer, Frank W.; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco García, Francico J; Haugen, Ida K.; Berenbaum, Francis; Lafeber, Floris P.J.G.; Welsing, Paco M.J.; Mastbergen, Simon C.; Wirth, Wolfgang (Springer, 2023-01-06)
      [Abstract] Objective: Longitudinal weight-bearing radiographic joint space width (JSW) and non-weight-bearing MRI-based cartilage thickness changes often show weak correlations. The current objective was to investigate ...
    • GaitSmart Motion Analysis Compared to Commonly Used Function Outcome Measures in the IMI-APPROACH Knee Osteoarthritis Cohort 

      van Helvoort, Eefje M.; Hodgings, Diana; Mastbergen, Simon; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Lafeber, Floris P.J.G.; Welsing, Paco M.J. (PLoS ONE, 2022-03-23)
      [Abstract] Background: There are multiple measures for assessment of physical function in knee osteoarthritis (OA), but each has its strengths and limitations. The GaitSmart® system, which uses inertial measurement units ...
    • Machine-learning predicted and actual 2-year structural progression in the IMI-APPROACH cohort 

      Jansen, Mylène P.; Wirth, Wolfgang; Bacardit, Jaume; van Helvoort, Eefje M.; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco García, Francico J; Haugen, Ida K.; Berenbaum, Francis; Ladel, Christoph H.; Loef, Marieke; Lafeber, Floris P.J.G.; Welsing, Paco M.J.; Mastbergen, Simon C.; Roemer, Frank W. (AME, 2023-05)
      [Abstract] In the Innovative Medicine’s Initiative Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) knee osteoarthritis (OA) study, machine learning models were trained to predict the ...
    • Neuropathic Pain in the IMI-APPROACH Knee Osteoarthritis Cohort: Prevalence and Phenotyping 

      van Helvoort, Eefje M.; Welsing, Paco M.J.; Jansen, Mylène P.; Gielis, Willem Paul; Loef, Marieke; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Bay-Jensen, Anne-C; Ladel, Christoph H.; Lalande, Agnes; Larkin, Jonathan; Loughlin, John; Mobasheri, Ali; Weinans, Harrie; Lafeber, Floris; Eijkelkamp, Niels; Mastbergen, Simon (BMJ, 2021-12-15)
      [Abstract] Objectives: Osteoarthritis (OA) patients with a neuropathic pain (NP) component may represent a specific phenotype. This study compares joint damage, pain and functional disability between knee OA patients with ...
    • OARSI Guidelines for the Non-Surgical Management of Knee, Hip, and Polyarticular Osteoarthritis 

      Bannuru, R.R.; Osani, M.C.; Vaysbrot, E.E.; Arden, Nigel; Bennell, K.; Bierma-Zeinstra, S.M.A.; Kraus, V.B.; Lohmander, L. Stefan; Abbott, J.H.; Bhandari, M.; Blanco García, Francisco J; Espinosa, R.; Haugen, Ida K.; Lin, J.; Mandl, L.A.; Moilanen, Eeva; Nakamura, N.; Synder-Mackler, L.; McAlindon, T.E. (Elsevier, 2019-11)
      [Abstract] Objective: To update and expand upon prior Osteoarthritis Research Society International (OARSI) guidelines by developing patient-focused treatment recommendations for individuals with Knee, Hip, and Polyarticular ...
    • Osteoarthritis endotype discovery via clustering of biochemical marker data 

      Angelini, Federico; Widera, Pawel; Mobasheri, Ali; Blair, Joseph; Struglics, André; Uebelhoer, Melanie; Hentorin, Yves; Marijnissen, Anne CA; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Ladel, Christoph; Larkin, Jonathan; Bay-Jensen, Anne C.; Bacardit, Jaume (BMJ, 2022-04-08)
      [Abstract] Objectives: Osteoarthritis (OA) patient stratification is an important challenge to design tailored treatments and drive drug development. Biochemical markers reflecting joint tissue turnover were measured in ...
    • Predicted and actual 2-year structural and pain progression in the IMI-APPROACH knee osteoarthritis cohort 

      van Helvoort, Eefje M.; Jansen, Mylène P.; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Bay-Jensen, Anne-C.; Ladel, Christoph; Lalande, Agnes; Larkin, Jonathan; Loughlin, John; Mobasheri, Ali; Weinans, Harrie; Widera, Pawel; Bacardit, Jaume; Welsing, Paco M.J.; Lafeber, Floris P.J.G. (Oxford Academic, 2023-01)
      [Abstract] Objectives: The IMI-APPROACH knee osteoarthritis study used machine learning (ML) to predict structural and/or pain progression, expressed by a structural (S) and pain (P) predicted-progression score, to select ...
    • Quantitative CT of the knee in the IMI-APPROACH osteoarthritis cohort: Association of bone mineral density with radiographic disease severity, meniscal coverage and meniscal extrusion 

      Heiss, Rafael; Laredo, Jean-Denis; Wirth, Wolfgang; Jansen, Mylène P.; Marijnissen, Anne C.A.; Lafeber, Floris P.J.G.; Lalande, Agnes; Weinans, Harrie H.; Blanco García, Francico J; Berenbaum, Francis; Kloppenburg, Margreet; Haugen, Ida K.; Engelke, Klaus; Roemer, Frank W. (Elsevier, 2023-03)
      [Abstract] Objective: Osteoarthritis (OA) is a highly prevalent chronic condition. The subchondral bone plays an important role in onset and progression of OA making it a potential treatment target for disease-modifying ...
    • Relationship Between Motion, Using the GaitSmartTM System, and Radiographic Knee Osteoarthritis: An Explorative Analysis in the IMI-APPROACH Cohort 

      van Helvoort, Eefje M.; Hodgins, Diana; Mastbergen, Simon C.; Marijnissen, Anne Karien; Guehring, Hans; Loef, Marieke; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Lafeber, Floris; Welsing, Paco M.J. (Oxford, 2020-12-25)
      [Abstract] Objectives: To assess underlying domains measured by GaitSmartTMparameters and whether these are additional to established OA markers including patient reported outcome measures (PROMs) and radiographic parameters, ...
    • Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort 

      Roemer, Frank W.; Jansen, Mylène; Marijnissen, Anne C.A.; Guermazi, Ali; Heiss, Rafael; Maschek, Susanne; Lalande, Agnes; Blanco García, Francisco J; Berenbaum, Francis; van de Stadt, Lotte A.; Kloppenburg, Margreet; Haugen, Ida K.; Ladel, Christoph H.; Bacardit, Jaume; Wisser, Anna; Eckstein, Felix; Lafeber, Floris P.J.G.; Weinans, Harrie H.; Wirth, Wolfgang (BioMed Central, 2022-11-17)
      [Abstract] Background. The IMI-APPROACH cohort is an exploratory, 5-centre, 2-year prospective follow-up study of knee osteoarthritis (OA). Aim was to describe baseline multi-tissue semiquantitative MRI evaluation of index ...
    • Test–retest precision and longitudinal cartilage thickness loss in the IMI-APPROACH cohort 

      Wirth, Wolfgang; Maschek, Susanne; Marijnissen, Anne C.A.; Lalande, Agnes; Blanco García, Francisco J; Berenbaum, Francis; van de Stadt, Lotte A.; Kloppenburg, Margreet; Haugen, Ida K.; Ladel, Christoph H.; Bacardit, Jaume; Wisser, Anna; Eckstein, Felix; Roemer, Frank W.; Lafeber, Floris P.J.G.; Weinans, Harrie H.; Jansen, Mylène (Elsevier, 2022-11-03)
      [Abstract] Objective. To investigate the test–retest precision and to report the longitudinal change in cartilage thickness, the percentage of knees with progression and the predictive value of the machine-learning-estimated ...
    • The association of the lipid profile with knee and hand osteoarthritis severity: the IMI-APPROACH cohort 

      Loef, Marieke; van de Stadt, L.; Böhringer, S.; Bay-Jensen, Anne-C.; Mobasheri, Ali; Larkin, Jonathan; Lafeber, Floris P.J.G.; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Giera, M.; Ioan-Facsinay, Andreea; Kloppenburg, Margreet (Elsevier, 2022-05-27)
      [Abstract] Objective: To investigate the association of the lipidomic profile with osteoarthritis (OA) severity, considering the outcomes radiographic knee and hand OA, pain and function. Design: We used baseline data ...