Listar por autor "Gómez-Reino, Juan J."

Mostrando ítems 1-6 de 6

    • Early and sustained efficacy with apremilast monotherapy in biological-naïve patients with psoriatic arthritis: a phase IIIB, randomised controlled trial (ACTIVE) 

      Nash, Peter; Ohson, Kamal; Walsh, Jessica; Delev, Nikolay; Nguyen, Dianne; Teng, Lichen; Gómez-Reino, Juan J.; Aelion, Jacob (BMJ, 2018-01-17)
      [Abstract] Objective Evaluate apremilast efficacy across various psoriatic arthritis (PsA) manifestations beginning at week 2 in biological-naïve patients with PsA. Methods Patients were randomised (1:1) to apremilast ...

    • Evaluation of 12 GWAS-drawn SNPs as biomarkers of rheumatoid arthritis response to TNF inhibitors. A potential SNP association with response to etanercept 

      Ferreiro-Iglesias, Aida; Montes, Ariana; Pérez-Pampin, Eva; Cañete, Juan D.; Raya, Enrique; Magro-Checa, César; Vasilopoulos, Yiannis; Cáliz, Rafael; Ferrer, Miguel Ángel; Joven, Beatriz; Carreira, Patricia; Balsa, Alejandro; Pascual-Salcedo, Dora; Blanco García, Francisco J; Moreno-Ramos, Manuel J.; Manrique-Arija, Sara; Ordoñez, María del Carmen; Alegre-Sancho, Juan J.; Narváez, Javier; Navarro-Sarabia, Federico; Moreira, Viriginia; Valor, Lara; García-Portales, Rosa; Márquez, Ana; Gómez-Reino, Juan J.; Martín, Javier; González, Antonio (PLoS, 2019-02-28)
      [Abstract] Research in rheumatoid arthritis (RA) is increasingly focused on the discovery of biomarkers that could enable personalized treatments. The genetic biomarkers associated with the response to TNF inhibitors (TNFi) ...

    • Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus 

      Alonso-Pérez, Elisa; Suárez-Gestal, Marian; Calaza, Manuel; Blanco García, Francisco J; Suárez, Ana; Santos, María José; Papasteriades, Chryssa; Carreira, Patricia; Pullmann, Rudolf; Ordi-Ros, Josep; Marchini, Maurizio; Skopouli, Fotini N.; Bijl, Marc; Barrizone, Nadia; Sebastiani, Gian Domenico; Migliaresi, Sergio; Witte, Torsten; Lauwerys, Bernard R.; Kovacs, Attila; Ruzickova, Sarka; Gómez-Reino, Juan J.; González, Antonio (BioMed Central, 2014-06-19)
      [Abstract] INTRODUCTION: We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was ...

    • Lack of replication of interactions between polymorphisms in rheumatoid arthritis susceptibility: case–control study 

      Ferreiro-Iglesias, Aida; Calaza, Manuel; Pérez-Pampin, Eva; López-Longo, J.; Marenco, José L.; Blanco García, Francisco J; Narváez, Javier; Navarro, Federico; Cañete, Juan D.; Rodríguez de la Serna, Arturo; González-Álvaro, Isidoro; Herrero-Beaumont, Gabriel; Pablos, José L.; Balsa, Alejandro; Fernández-Gutiérrez, Benjamín; Cáliz, Rafael; Gómez-Reino, Juan J.; González, Antonio (BioMed Central, 2014-09-27)
      [Abstract] INTRODUCTION: Approximately 100 loci have been definitively associated with rheumatoid arthritis (RA) susceptibility. However, they explain only a fraction of RA heritability. Interactions between polymorphisms ...

    • Specific premature epigenetic aging of cartilage in osteoarthritis 

      Vidal-Bravo, Laura; López-Golán, Yolanda; Mera-Varela, Antonio; Rego-Pérez, Ignacio; Horvath, Steve; Zhang, Yuhua; Real, Álvaro del; Zhai, Guangju; Blanco García, Francisco J; Riancho, José A.; Gómez-Reino, Juan J.; González, Antonio (Impact Journals, 2016-09-28)
      [Abstract] Osteoarthritis (OA) is a disease affecting multiple tissues of the joints in the elderly, but most notably articular cartilage. Premature biological aging has been described in this tissue and in blood cells, ...

    • Validation study of genetic biomarkers of response to TNF inhibitors in rheumatoid arthritis 

      López-Rodríguez, Rosario; Pérez-Pampin, Eva; Márquez, Ana; Blanco García, Francisco J; Joven, Beatriz; Carreira, Patricia; Ferrer, Miguel Ángel; Cáliz, Rafael; Valor, Lara; Narváez, Javier; Cañete, Juan D.; Ordóñez, María del Carmen; Manrique-Arija, Sara; Vasilopoulos, Yiannis; Balsa, Alejandro; Pascual-Salcedo, Dora; Moreno-Ramos, Manuel J.; Alegre-Sancho, Juan José; Navarro-Sarabia, Federico; Moreira, Virginia; García-Portales, Rosa; Raya, Enrique; Magro-Checa, Rosa; Martín, Javier; Gómez-Reino, Juan J.; González, Antonio (PLoS, 2018-05-07)
      [Abstract] Genetic biomarkers are sought to personalize treatment of patients with rheumatoid arthritis (RA), given their variable response to TNF inhibitors (TNFi). However, no genetic biomaker is yet sufficiently validated. ...