Listar por autor "Eleftheriadou, Olga"

Mostrando ítems 1-2 de 2

    • Genome Wide CRISPR/Cas9 Screen Identifies the Coagulation Factor IX (F9) as a Regulator of Senescence 

      Carpintero-Fernández, Paula; Borghesan, Michela; Eleftheriadou, Olga; Pan-Castillo, Belén; Fafián Labora, Juan Antonio; Mitchell, Tom P.; Yuste, Alejandro; Ogrunc, Muge; Nightingale, Thomas D.; Mayán, María; O'Loghlen, Ana (Nature, 2022-02-19)
      [Abstract] During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression. In this context, CDK4/6 inhibitors induce ...

    • Small extracellular vesicles are key regulators of non-cell autonomous intercellular communication in senescence via the interferon protein IFITM3 

      Borghesan, Michela; Fafián Labora, Juan Antonio; Eleftheriadou, Olga; Carpintero-Fernández, Paula; Paez-Ribes, Marta; Vizcay-Barrena, Gema; Swisa, Avital; Kolodkin-Gal, Dror; Ximénez-Embún, Pilar; Lowe, Robert; Martín-Martín, Belén; Peinado, Héctor; Muñoz, Javier; Fleck, Roland A.; Dor, Yuval; Ben-Porath, Ittai; Vossenkamper, Anna; Muñoz-Espin, Daniel; O’Loghlen, Ana (Cell Press, 2019-06-25)
      [Abstract] Senescence is a cellular phenotype present in health and disease, characterized by a stable cell-cycle arrest and an inflammatory response called senescence-associated secretory phenotype (SASP). The SASP is ...