Listar por autor "Carpintero-Fernández, Paula"
Mostrando ítems 1-3 de 3
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Extracellular Vesicles Enriched in Connexin 43 Promote a Senescent Phenotype in Bone and Synovial Cells Contributing to Osteoarthritis Progression
Varela-Eirín, Marta; Carpintero-Fernández, Paula; Guitián-Caamaño, Amanda; Varela Vázquez, Adrián; García-Yuste, Alejandro; Sánchez Temprano, Agustín; Bravo López, Susana Belén; Yáñez-Cabanas, José; Fonseca, Eduardo; Largo, R.; Mobasheri, Ali; Caeiro, José Ramón; Mayán, María D. (Springer Nature, 2022)[Abstract] The accumulation of senescent cells is a key characteristic of aging, leading to the progression of age-related diseases such as osteoarthritis (OA). Previous data from our laboratory has demonstrated that high ... -
Genome Wide CRISPR/Cas9 Screen Identifies the Coagulation Factor IX (F9) as a Regulator of Senescence
Carpintero-Fernández, Paula; Borghesan, Michela; Eleftheriadou, Olga; Pan-Castillo, Belén; Fafián Labora, Juan Antonio; Mitchell, Tom P.; Yuste, Alejandro; Ogrunc, Muge; Nightingale, Thomas D.; Mayán, María; O'Loghlen, Ana (Nature, 2022-02-19)[Abstract] During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression. In this context, CDK4/6 inhibitors induce ... -
Senolytic Activity of Small Molecular Polyphenols from Olive Restores Chondrocyte Redifferentiation and Promotes a Pro-Regenerative Environment in Osteoarthritis
Varela-Eirín, Marta; Carpintero-Fernández, Paula; Sánchez Temprano, Agustín; Varela Vázquez, Adrián; Luis Paíno, Carlos; Casado-Díaz, Antonio; Calañas Continente, Alfonso; Mato-Abad, Virginia; Fonseca, Eduardo; Kandouz, Mustapha; Blanco, Alfonso; Caeiro, José Ramón; Mayan, Maria D. (Impact Journals LLC, 2020-08-03)[Abstract] Articular cartilage and synovial tissue from patients with osteoarthritis (OA) show an overactivity of connexin43 (Cx43) and accumulation of senescent cells associated with disrupted tissue regeneration and ...