Listar por autor "Pásaro, Eduardo"

Mostrando ítems 21-40 de 40

    • Identification of Differentially Expressed Genes in SHSY5Y Cells Exposed to Okadaic Acid by Suppression Subtractive Hybridization 

      Valdiglesias, Vanessa; Fernández-Tajes, Juan; Pásaro, Eduardo; Méndez, Josefina; Laffon, Blanca (Springer Nature, 2012-01-27)
      [Abstract] Background: Okadaic acid (OA), a toxin produced by several dinoflagellate species is responsible for frequent food poisonings associated to shellfish consumption. Although several studies have documented the OA ...

    • Immune activation in older-aged individuals is associated with genetic instability (or vice versa) 

      Gostner, Johanna; Sánchez-Flores, María; Marcos-Pérez, Diego; Lorenzo-López, Laura; Maseda, Ana; Millán-Calenti, José Carlos; Fuchs, Dietmar; Bonassi, Stefano; Pásaro, Eduardo; Laffon, Blanca; Valdiglesias, Vanessa (De Gruyter, 2019-06-15)

    • Immune biomarkers in older adults: role of physical activity 

      Valdiglesias, Vanessa; Sánchez-Flores, María; Maseda, Ana; Lorenzo-López, Laura; Marcos Pérez, Diego; López-Cortón-Facal, Ana; Strasser, Barbara; Fuchs, Dietmar; Laffon, Blanca; Millán-Calenti, José Carlos; Pásaro, Eduardo (Taylor & Francis, 2017-05-19)
      [Abstract] Aging is associated with a decline in the normal functioning of the immune system. Several studies described the relationship between immunological alterations, including immunosenescence and inflammation, and ...

    • Implications of the Estrogen Receptor Coactivators SRC1 and SRC2 in the Biological Basis of Gender Incongruence 

      Del Valle Ramírez, Karla; Fernández, Rosa; Delgado-Zayas, Enrique; Gómez-Gil, Esther; Esteva, Isabel; Guillamon, Antonio; Pásaro, Eduardo (2021)
      [Abstract] Introduction Brain sexual differentiation results from the effects of sex steroids on the developing brain. The presumptive route for brain masculinization is the direct induction of gene expression via activation ...

    • Induction of Oxidative DNA Damage by the Marine Toxin Okadaic Acid Depends on Human Cell Type 

      Valdiglesias, Vanessa; Laffon, Blanca; Pásaro, Eduardo; Cemeli, Eduardo; Anderson, Diana; Méndez, Josefina (Elsevier, 2011-03-01)
      [Abstract] The marine toxin okadaic acid (OA) is the main representative of diarrhoeic shellfish poisoning (DSP) toxins. Its ingestion induces nausea, vomiting, diarrhoea and abdominal ache. It has also been found to trigger ...

    • Is salivary chromogranin A a valid psychological stress biomarker during sensory stimulation in people with advanced dementia? 

      Valdiglesias, Vanessa; Maseda, Ana; Lorenzo-López, Laura; Pásaro, Eduardo; Millán-Calenti, José Carlos; Laffon, Blanca (IOS Press, 2016-12-20)
      [Abstract] Salivary chromogranin A (sCgA) is gaining attention as a biomarker of psychological stress. The objective of this work was to determine whether individualized music intervention and multisensory stimulation ...

    • Low Vitamin D Levels and Frailty Status in Older Adults: a Systematic Review and Meta-Analysis 

      Marcos-Pérez, Diego; Sánchez-Flores, María; Bonassi, Stefano; Costa, Solange; Teixeira, João; Fernández-Tajes, Juan; Pásaro, Eduardo; Valdiglesias, Vanessa; Laffon, Blanca (2020)
      [Abstract] Serum vitamin D deficiency is widespread among older adults and is a potential modifiable risk factor for frailty. Moreover, frailty has been suggested as an intermediate step in the association between low ...

    • Lymphocyte subsets in a population of nonfrail elderly individuals 

      Valdiglesias, Vanessa; Sánchez-Flores, María; Maseda, Ana; Marcos Pérez, Diego; Millán-Calenti, José Carlos; Pásaro, Eduardo; Lorenzo-López, Laura; Laffon, Blanca (Taylor & Francis, 2015-07-13)
      [Abstract] Age-related frailty is characterized by increased vulnerability to stress due to decline in homeostatic reserve, which results in increased risk of adverse health outcomes including disability, hospitalization, ...

    • Molecular basis of Gender Dysphoria: androgen and estrogen receptor interaction 

      Fernández, Rosa; Guillamón, Antonio; Cortés-Cortés, Joselyn; Gómez-Gil, Esther; Jácome, M. A.; Esteva, Isabel; Almaraz, Mari Cruz; Mora, Mireia; Aranda, Gloria; Pásaro, Eduardo (Elsevier, 2018-08-27)
      [Abstract] Background: Polymorphisms in sex steroid receptors have been associated with transsexualism. However, published replication studies have yielded inconsistent findings, possibly because of a limited sample size ...

    • Neuronal Cytotoxicity and Genotoxicity Induced by Zinc Oxide Nanoparticles 

      Valdiglesias, Vanessa; Costa, C.; Kiliç, Gözde; Costa, Solange; Pásaro, Eduardo; Laffon, Blanca; Teixeira, João Paulo (Elsevier, 2013-03-26)
      [Abstract] Zinc oxide nanoparticles (ZnO NPs) are one of the most abundantly used nanomaterials in consumer products and biomedical applications. As a result, human exposure to these NPs is highly frequent and they have ...

    • Okadaic Acid Induces Morphological Changes, Apoptosis and Cell Cycle Alterations in Different Human Cell Types 

      Valdiglesias, Vanessa; Laffon, Blanca; Pásaro, Eduardo; Méndez, Josefina (Royal Society of Chemistry (Gran Bretaña), 2011-03-28)
      [Abstract] Okadaic acid (OA) is a marine toxin produced by dinoflagellate species which is frequently accumulated in molluscs usual in the human diet. The exact action mechanism of OA has not been described yet and the ...

    • Okadaic Acid: More than a Diarrheic Toxin 

      Valdiglesias, Vanessa; Prego-Faraldo, María Verónica; Pásaro, Eduardo; Méndez, Josefina; Laffon, Blanca (Multidisciplinary Digital Publishing Institute, 2013)
      Okadaic acid (OA) is one of the most frequent and worldwide distributed marine toxins. It is easily accumulated by shellfish, mainly bivalve mollusks and fish, and, subsequently, can be consumed by humans causing alimentary ...

    • Reference ranges of lymphocyte subsets in non-frail older adults 

      Laffon, Blanca; Sánchez-Flores, María; Marcos-Pérez, Diego; Maseda, Ana; Lorenzo-López, Laura; Millán-Calenti, José Carlos; Valdiglesias, Vanessa; Pásaro, Eduardo (Oxford, 2017-06-30)

    • Relationship between DNA damage measured by the comet-assay and cognitive function 

      Lorenzo-López, Laura; Lema-Arranz, Carlota; Fernández-Bertólez, Natalia; Costa, Solange; Costa, Carla; Teixeira, Joao Paulo; Pásaro, Eduardo; Valdiglesias, Vanessa; Laffon, Blanca (Elsevier, 2022-10-17)
      [Abstract] Recent studies exploring the relationship between DNA damage measured by the comet assay (single-cell gel electrophoresis) and cognitive function in both animal models and humans are reviewed and summarized. ...

    • Salivary Leucocytes as In Vitro Model to Evaluate Nanoparticle-Induced DNA Damage 

      Valdiglesias, Vanessa; Fernández-Bertólez, Natalia; Lema-Arranz, Carlota; Rodríguez-Fernández, Raquel; Pásaro, Eduardo; Reis, Ana Teresa; Teixeira, João; Costa, C.; Laffon, Blanca (MDPI, 2021-07-27)
      [Abstract] Metal oxide nanoparticles (NPs) have a wide variety of applications in many consumer products and biomedical practices. As a result, human exposure to these nanomaterials is highly frequent, becoming an issue ...

    • Serum cortisol but not oxidative stress biomarkers are related to frailty: results of a cross-sectional study in Spanish older adults 

      Marcos-Pérez, Diego; Sánchez-Flores, María; Maseda, Ana; Lorenzo-López, Laura; Millán-Calenti, José Carlos; Pásaro, Eduardo; Laffon, Blanca; Valdiglesias, Vanessa (Taylor&Francis, 2019-08-13)
      [Abstract] Frailty is a multidimensional geriatric syndrome of loss of reserves and increased vulnerability to negative health outcomes. Cortisol, the major hormone of the hypothalamic pituitary adrenal (HPA) axis, and ...

    • Suitability of the In Vitro Cytokinesis-Block Micronucleus Test for Genotoxicity Assessment of TiO2 Nanoparticles on SH-SY5Y Cells 

      Fernández-Bertólez, Natalia; Brandão, Fátima; Costa, C.; Pásaro, Eduardo; Teixeira, João; Laffon, Blanca; Valdiglesias, Vanessa (2021)
      [Abstract] Standard toxicity tests might not be fully adequate for evaluating nanomaterials since their unique features are also responsible for unexpected interactions. The in vitro cytokinesis-block micronucleus (CBMN) ...

    • The Marine Toxin Okadaic Acid Induces Alterations in the Expression Level of Cancer-Related Genes in Human Neuronal Cells 

      Valdiglesias, Vanessa; Fernández-Tajes, Juan; Méndez, Josefina; Pásaro, Eduardo; Laffon, Blanca (Elsevier, 2013-04-03)
      [Abstract] Okadaic acid (OA) is one of the most common and highly distributed marine toxins. It can be accumulated in several molluscs and other marine organisms and cause acute gastrointestinal symptoms after oral consumption ...

    • The Organic Selenium Compound Selenomethionine Modulates Bleomycin-Induced DNA Damage and Repair in Human Leukocytes 

      Laffon, Blanca; Valdiglesias, Vanessa; Pásaro, Eduardo; Méndez, Josefina (Springer, 2009-05-08)
      [Abstract] The objective of this work was to evaluate the effects of selenomethionine (SeMet) on the induction, repair, and persistence of DNA damage in human leukocytes challenged with bleomycin (BLM). Comet assay was ...

    • Toxoplasma gondii IgG serointensity is positively associated with frailty 

      Mohyuddin, Hira; Laffon, Blanca; Teixeira, Joao P.; Costa, Solange; Teixeira-Gomes, Armanda; Pásaro, Eduardo; Constantine, Niel; Dagdag, Aline; Ortmeyer, Heidi K.; Tizenberg, Boris; Afram, Liubov; Yen, Poyu; Marano, Christopher; Lowry, Christopher A.; Hoisington, Andrew J.; RachBeisel, Jill A.; Valdiglesias, Vanessa; Lema-Arranz, Carlota; Fernández-Bertólez, Natalia; Maseda, Ana; Millán-Calenti, José Carlos; Kovacs, Elizabeth J.; Gostner, Johanna M.; Fuchs, Dietmar; Brenner, Lisa A.; Lorenzo-López, Laura; Postolache, Teodor T. (Oxford University Press, 2023-11-06)
      [Abstract] Background: Persistent inflammation related to aging ("inflammaging") is exacerbated by chronic infections and contributes to frailty in older adults. We hypothesized associations between Toxoplasma gondii (T. ...