Listar por autor "Blanco García, Francisco J"
Mostrando ítems 41-60 de 189
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Defective chaperone-mediated autophagy is a hallmark of joint disease in patients with knee osteoarthritis
Lorenzo-Gómez, I.; Nogueira Recalde, Uxía; García-Domínguez, C.; Oreiro, Natividad; Lotz, Martin; Pinto-Tasende, José A.; Blanco García, Francisco J; Caramés, Beatriz (Elsevier, 2023-03-08)[Abstract] Objective: Defects in autophagy contribute to joint aging and Osteoarthritis (OA). Identifying specific autophagy types could be useful for developing novel treatments for OA. Design: An autophagy-related ... -
Descripción de la cohorte PROCOAC (PROspective COhort of A Coruña): cohorte prospectiva española para el estudio de la osteoartritis
Oreiro, Natividad; Raga, Ana C.; Rego-Pérez, Ignacio; Pértega-Díaz, Sonia; Silva-Díaz, María T.; Freire, Mercedes; Fernández-López, Carlos; Blanco García, Francisco J (Elsevier, 2020-11-13)[Resumen] Introducción y objetivo. El uso de cohortes de osteoartritis bien caracterizadas es obligatorio para estudiar y profundizar en el conocimiento en esta enfermedad. En España no existe actualmente ninguna cohorte ... -
Design of a digital-PCR assay to quantify fragmented human mitochondrial DNA
Mosquera, Alejandro; Guillén, Rebeca; Otero, Fátima; Rego-Pérez, Ignacio; Blanco García, Francisco J; Fernández, José Luis (Wiley, 2021-06-11)[Abstract] Digital PCR (dPCR) has been adapted to quantify the proportion of mitochondrial DNA (mtDNA) molecules without and with double-strand DNA breaks (DSBs). This is based on a break-apart approach of two differentially ... -
Differentiation of human mesenchymal stromal cells cultured on collagen sponges for cartilage repair
Sanjurjo-Rodríguez, Clara; Martínez Sánchez, Adela Helvia; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Blanco García, Francisco J (Sociedad Española de Histología e Ingeniería Tisular, 2016)[Abstract] Aim: The aim of this study was to evaluate proliferation and chondrogenic differentiation of human bone-marrow mesenchymal stromal cells (hBMSCs) cultured on collagen biomaterials. Materials and methods: ... -
Differentiation of Synovial CD-105+ Human Mesenchymal Stem Cells into Chondrocyte-like Cells through Spheroid Formation
Arufe, M.C.; Fuente, Alexandre de la; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Wiley, 2009-06-18)[Abstract] Mesenchymal stem cells (MSCs) have the capacity to differentiate into several cell lineages, some of which can generate bone, cartilage, or adipose tissue. The presence of MSCs in the synovial membrane was ... -
Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the Osteoarthritis Initiative
Camacho Encina, María; Balboa-Barreiro, Vanesa; Rego-Pérez, Ignacio; Picchi, Florencia; VanDuin, Jennifer; Qiu, Ji; Fuentes, Manuel; Oreiro, Natividad; LaBaer, Joshua; Ruiz-Romero, Cristina; Blanco García, Francisco J (BMJ, 2019-08-30)[Abstract] Objective To find autoantibodies (AAbs) in serum that could be useful to predict incidence of radiographic knee osteoarthritis (KOA). Design A Nucleic-acid Programmable Protein Arrays (NAPPA) platform was ... -
Discovery of circulating proteins associated to knee radiographic osteoarthritis
Lourido Salas, Lucía María; Ayoglu, Burcu; Fernández-Tajes, Juan; Oreiro, Natividad; Henjes, Frauke; Hellström, Cecilia; Schwenk, Jochen M.; Ruiz-Romero, Cristina; Nilsson, Peter; Blanco García, Francisco J (Nature, 2017-03-09)[Abstract] Currently there are no sufficiently sensitive biomarkers able to reflect changes in joint remodelling during osteoarthritis (OA). In this work, we took an affinity proteomic approach to profile serum samples for ... -
Effect of balneotherapy in sulfurous water on an in vivo murine model of osteoarthritis
Vaamonde-García, Carlos; Vela Anero, Ángela; Hermida Gómez, Tamara; Burguera, Elena F.; Filgueira-Fernández, P.; Goyanes, Noa; Blanco García, Francisco J; Meijide-Faílde, Rosa (Springer, 2019-11-01)[Abstract] Osteoarthritis (OA) is a chronic joint disease that results in progressive cartilage destruction and subsequently joint dysfunction. Growing evidence indicates beneficial impact of balneological interventions ... -
Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1β-stimulated human articular chondrocytes
Burguera, Elena F.; Vela-Anero, Á.; Magalhaes, J.; Meijide-Faílde, Rosa; Blanco García, Francisco J (Elsevier, 2014-07)[Abstract] Objective. Hydrogen sulfide (H2S), the third gasotransmitter together with NO and CO, is emerging as a regulator of inflammation. To test if it might offer therapeutic value in the treatment of osteoarthritis ... -
Effectiveness of tapentadol prolonged release (PR) compared with oxycodone/naloxone PR for the management of severe chronic low back pain with a neuropathic component: a randomized, controlled, open‐label, phase 3b/4sStudy
Baron, Ralf; Likar, Rudolf; Martín-Mola, Emilio; Blanco García, Francisco J; Kennes, Lieven; Müller, Matthias; Falke, Dietmar; Steigerwald, Ilona (Wiley, 2015-06-12)[Abstract] OBJECTIVE: To evaluate the effectiveness of tapentadol prolonged release (PR) vs. oxycodone/naloxone PR in non-opioid-pretreated patients with severe chronic low back pain with a neuropathic pain component. ... -
Effects of severe hypoxia on bone marrow mesenchymal stem cells differentiation potential
Cicione, Claudia; Muiños-López, Emma; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Blanco García, Francisco J (Hindawi, 2013-06-30)[Abstract] Background. The interests in mesenchymal stem cells (MSCs) and their application in cell therapy have resulted in a better understanding of the basic biology of these cells. Recently hypoxia has been indicated ... -
Epigenetics as a therapeutic target in osteoarthritis
Núñez-Carro, Carmen; Blanco-Blanco, Margarita; Villagrán-Andrade, Karla Mariuxi; Blanco García, Francisco J; Andrés, María C. de (MDPI, 2023-01-21)[Abstract] Osteoarthritis (OA) is a heterogenous, complex disease affecting the integrity of diarthrodial joints that, despite its high prevalence worldwide, lacks effective treatment. In recent years it has been discovered ... -
Establishment of human induced pluripotent stem cell-lines (IPSC) for in vitro modelling hand ostheoarthritis.
Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (BMJ Journals, 2019-05-27) -
Estudio "in vitro" del efecto del óxido nítrico sobre los condrocitos articulares humanos : proliferación, viabilidad y envejecimiento
Blanco García, Francisco J (1998) -
Etanercept withdrawal and retreatment in nonradiographic axial spondyloarthritis: results of RE-EMBARK, an open-label phase IV trial
Van den Bosch, Filip; Wei, James Cheng-Chung; Nash, Peter; Blanco García, Francisco J; Graham, Daniela; Zang, Chuanbo; Arthur, Edmund; Borlenghi, Cecilia; Tsekouras, Vassilis; Vlahos, Bonnie; Deodhar, Atul (Journal of Rheumatology Publishing, 2023-04)[Abstract] Objective: RE-EMBARK investigated etanercept (ETN) withdrawal and retreatment in patients with nonradiographic axial spondyloarthritis (nr-axSpA) achieving inactive disease. Methods: Patients received ETN and ... -
Evaluación económica de la monoterapia con tocilizumab frente a adalimumab en artritis reumatoide
Navarro-Sarabia, Federico; Blanco García, Francisco J; Álvaro Gracia, José María; García Meijide, Juan A.; Poveda, José Luis; Rubio-Rodríguez, Darío; Rubio-Terrés, Carlos (Ministerio de Sanidad, Consumo y Bienestar Social, 2013)[Resumen] Fundamento: Tocilizumab (TCZ) fue superior a adalimumab (ADA) en monoterapia en la reducción de los signos y síntomas de la artritis reumatoide del adulto (AR) en pacientes intolerantes o con respuesta inadecuada ... -
Evaluation of 12 GWAS-drawn SNPs as biomarkers of rheumatoid arthritis response to TNF inhibitors. A potential SNP association with response to etanercept
Ferreiro-Iglesias, Aida; Montes, Ariana; Pérez-Pampin, Eva; Cañete, Juan D.; Raya, Enrique; Magro-Checa, César; Vasilopoulos, Yiannis; Cáliz, Rafael; Ferrer, Miguel Ángel; Joven, Beatriz; Carreira, Patricia; Balsa, Alejandro; Pascual-Salcedo, Dora; Blanco García, Francisco J; Moreno-Ramos, Manuel J.; Manrique-Arija, Sara; Ordoñez, María del Carmen; Alegre-Sancho, Juan J.; Narváez, Javier; Navarro-Sarabia, Federico; Moreira, Viriginia; Valor, Lara; García-Portales, Rosa; Márquez, Ana; Gómez-Reino, Juan J.; Martín, Javier; González, Antonio (PLoS, 2019-02-28)[Abstract] Research in rheumatoid arthritis (RA) is increasingly focused on the discovery of biomarkers that could enable personalized treatments. The genetic biomarkers associated with the response to TNF inhibitors (TNFi) ... -
Exploring high-throughput immunoassays for biomarker validation in rheumatic diseases in the context of the human proteome project
Fuentes, Manuel; Ruiz-Romero, Cristina; Misiego, Sara; Juanes-Velasco, Pablo; Landeira-Viñuela, Alicia; Torres-Roda, Adrián; Lorenzo-Gil, Héctor; González-González, María; Hernández, Ángela P.; Lourido, Lucía; Sjöberg, Ronald; Pin, Elisa; Las Rivas, Javier de; Sánchez-Santos, José Manuel; Nilsson, Peter; Blanco García, Francisco J (ACS Publications, 2022-12-07)[Abstract] Rheumatic diseases are high prevalence pathologies with different etiology and evolution and low sensitivity in clinical diagnosis. Therefore, it is necessary to develop an early diagnosis method which allows ... -
Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy
Nogueira Recalde, Uxía; Lorenzo Gómez, Irene; Blanco García, Francisco J; Loza, María Isabel; Grassi, Diego; Shirinsky, Valery; Shirinsky, Ivan; Lotz, Martin; Robbins, Paul D.; Domínguez, Eduardo; Caramés, Beatriz (Elsevier, 2019-07-05)[Abstract] Background. Ageing-related failure of homeostasis mechanisms contributes to articular cartilage degeneration and osteoarthritis (OA), for which disease-modifying treatments are not available. Our objective was ... -
GaitSmart Motion Analysis Compared to Commonly Used Function Outcome Measures in the IMI-APPROACH Knee Osteoarthritis Cohort
van Helvoort, Eefje M.; Hodgings, Diana; Mastbergen, Simon; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Lafeber, Floris P.J.G.; Welsing, Paco M.J. (PLoS ONE, 2022-03-23)[Abstract] Background: There are multiple measures for assessment of physical function in knee osteoarthritis (OA), but each has its strengths and limitations. The GaitSmart® system, which uses inertial measurement units ...