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Role of neurokinin B in the control of female puberty and Its modulation by metabolic status
(Society of Neuroscience, 2012-02-15)
[Abstract] Human genetic studies have revealed that neurokinin B (NKB) and its receptor, neurokinin-3 receptor (NK3R), are essential elements for normal reproduction; however, the precise role of NKB–NK3R signaling in the ...
Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3
(Public Library of Science (PLoS), 2019-11-07)
[Abstract]
Mkrn3, the maternally imprinted gene encoding the makorin RING-finger protein-3, has
recently emerged as putative pubertal repressor, as evidenced by central precocity caused
by MKRN3 mutations in humans; ...
Testicular expression of the Lin28/let-7 system: hormonal regulation and changes during postnatal maturation and after manipulations of puberty
(Nature, 2015-10-23)
[Abstract] The Lin28/let-7 system, which includes the RNA-binding proteins, Lin28a/Lin28b, and let-7 miRNAs, has emerged as putative regulator of puberty and male gametogenesis; yet, its expression pattern and regulation ...
Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism
(Endocrine Society, 2013-01-21)
[Abstract] Lin28 (also termed Lin28a) and Lin28b are related RNA-binding proteins, involved in the control of microRNA synthesis, especially of the let-7 family, with putative functions in early (embryo) development. ...
Changes in hypothalamic expression of the Lin28/let-7 system and related MicroRNAs during postnatal maturation and after experimental manipulations of puberty
(Endocrine Society, 2013)
[Abstract] Lin28 and Lin28b are related RNA-binding proteins that inhibit the maturation of miRNAs of the let-7 family and participate in the control of cellular stemness and early embryonic development. Considerable ...
Perturbation of hypothalamic MicroRNA expression patterns in male rats after metabolic distress: impact of obesity and conditions of negative energy balance
(Endocrine Society, 2014-02-11)
[Abstract] The hypothalamus plays a crucial role in body weight homeostasis through an intricate network of neuronal circuits that are under the precise regulation of peripheral hormones and central transmitters. Although ...